Valproic Acid: A Reappraisal of Its Pharmacological Properties and Clinical Efficacy in Epilepsy

    February 1994 in “ PubMed ”
    Rick Davis, David H. Peters, Donna McTavish
    TLDR Valproic acid is an effective and safe first-choice treatment for many types of seizures.
    Valproic acid, a branched-chained fatty acid, was found to be effective and safe for treating various types of seizures in both adults and children, including generalized seizures (absence, tonic-clonic, myoclonic), partial seizures, and compound/combination seizures. It showed efficacy comparable to other antiepileptic drugs like carbamazepine and phenytoin. Common side effects included gastrointestinal issues, weight gain, tremor, and transient hair loss, with minimal neurological adverse effects. The risk of rare, fatal liver failure was reduced by avoiding use in high-risk patients. There was a reported 1-2% risk of neural tube defects with maternal use. Valproic acid's interaction with other drugs required careful dosage adjustments. Overall, it was considered a valuable first-line treatment for a broad range of seizure types.
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      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  7 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

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      in Question  2 upvotes 7 years ago
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      in Treatment  9 upvotes 2 years ago
      User tries dermapen for hair loss and plans to use non-mainstream topicals like c60, ghk-cu, and ptd-dbm with valproic acid. They also use a head massager and modified LLLT belt for additional treatment.

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