Short-Term Side Effects of Low Dose Valproate Monotherapy in Epileptic Children: A Prospective Study

    January 2019 in “ PubMed ”
    Parisa Nasr Esfahani, Jafar Nasiri, Shervin Badihian, Omid Yaghini
    TLDR Low dose valproate in epileptic children mainly causes weight gain and other non-life-threatening side effects.
    The study investigated the short-term side effects of low-dose valproate monotherapy in 209 epileptic children over 6 months. The most common side effect was weight gain, reported in 53.1% of patients. Other side effects included decreased appetite (11%), abdominal pain (16.3%), headache (5.7%), enuresis (8.1%), hair loss (6.7%), and various gastrointestinal and neurological symptoms. Serious side effects like thrombocytopenia, impaired liver function, and leukopenia were rare, each occurring in about 1% of patients. The study concluded that while low-dose valproate could cause numerous side effects, most were not life-threatening and did not require intervention.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 18 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  51 upvotes 1 month ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community New & Improved Hair Growth Stack for Maximum Results

      in Treatment  2 upvotes 2 months ago
      A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

      community 6 months before and after pics: VDPHL01 (oral minoxidil)

      in Progress Pictures  107 upvotes 1 month ago
      A user shared their positive experience with a clinical trial for a new oral medication, VDPHL01, which is a reformulated version of oral minoxidil taken at a high dose of 17mg daily, showing significant hair regrowth after six months. The user noted that this formulation is believed to be more effective and time-released, with fewer side effects compared to regular oral minoxidil.

      community Found the solution tressbros - 1.5 years 2.5mg oral minox, 5mg finasteride, 8mg estradiol valerate (weekly)

      in Transgender  591 upvotes 1 year ago
      The conversation discusses a transgender individual's successful hair loss treatment over 1.5 years using 2.5mg oral minoxidil, 5mg finasteride, and 8mg weekly injectable estradiol valerate. Some users debate the appropriateness of this approach within the group's goals, while others support the individualized treatment and its additional benefits for transgender individuals.

    Related Research

    1 / 1 results