A 6-Month Prospective Study on Efficacy, Safety, and Quality of Life Profiles of Extended-Release Formulation of Valproate in Patients with Epilepsy

    October 2010 in “ Seizure ”
    Peimin Yu, Guangfa Zhu, Xunyi Wu, Ting Li, Lan Xu, Yue Li, Bei Wang, Zhen Hong
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    TLDR Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.
    In a 6-month prospective study involving 958 epilepsy patients, the extended-release (ER) formulation of valproate was evaluated for efficacy, safety, and quality of life impact. The study found that the ER valproate, used as initial or add-on therapy, significantly reduced seizure frequency by 88.3% from a baseline mean of 8.56 seizures per month, with patients taking a median maintenance dose of 750 mg per day. Quality of life improvements were noted in areas such as seizure worry, overall quality of life, and social function, although energy levels decreased. Early treatment side effects included drowsiness, dizziness, and anorexia, while weight gain, alopecia, and tremor were reported after 6 months. Overall, the ER valproate was shown to be effective in reducing seizures with good tolerance and enhanced quality of life for patients.
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