A 6-Month Prospective Study on Efficacy, Safety, and Quality of Life Profiles of Extended-Release Formulation of Valproate in Patients with Epilepsy

    October 2010 in “ Seizure ”
    Peimin Yu, Guangfa Zhu, Xunyi Wu, Ting Li, Lan Xu, Yue Li, Bei Wang, Zhen Hong
    Image of study
    TLDR Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.
    In a 6-month prospective study involving 958 epilepsy patients, the extended-release (ER) formulation of valproate was evaluated for efficacy, safety, and quality of life impact. The study found that the ER valproate, used as initial or add-on therapy, significantly reduced seizure frequency by 88.3% from a baseline mean of 8.56 seizures per month, with patients taking a median maintenance dose of 750 mg per day. Quality of life improvements were noted in areas such as seizure worry, overall quality of life, and social function, although energy levels decreased. Early treatment side effects included drowsiness, dizziness, and anorexia, while weight gain, alopecia, and tremor were reported after 6 months. Overall, the ER valproate was shown to be effective in reducing seizures with good tolerance and enhanced quality of life for patients.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Shedding again after 6 months of great results.

      in Minoxidil  15 upvotes 1 year ago
      A user experienced shedding after 7 months on Fin/Min spray despite good results and no change in treatment. Other users noted similar experiences and mentioned that shedding periods can be normal.

      community My experience with rosemary oil

      in Product  42 upvotes 3 years ago
      The user's experience with rosemary oil as a hair loss treatment and its effectiveness; they discuss other treatments such as finasteride, minoxidil, and RU58841; there is also discussion of combining oils like peppermint oil, zix, and dermapen.

      community Could you tell this is a hair system?

      in Technology  307 upvotes 3 years ago
      A user who was losing their hair and found an effective solution; they asked for opinions on it and discussed treatments such as Minoxidil, Finasteride, and RU58841, as well as SMP.

      community 11 months on fin only. Regrowth + thickness

      in Progress Pictures  572 upvotes 2 years ago
      A user reported hair regrowth and increased thickness after 11 months using finasteride 1mg, taken 3-4 times a week, with noticeable improvement starting around the third or fourth month. No side effects were mentioned, and the user is considering reducing the dosage to find the minimum needed to maintain results.

    Similar Research

    6 / 1000+ results