Increasing activity of the sult1a1 enzyme via alkalizing agent and tretinoin for better response to topical minoxidil Research/Science 8/7/2024
Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzyme activity and minoxidil effectiveness.
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5 / 72 resultscommunity Minoxidil works only with Retinoic acid
Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.
community Reasons why Topical worked but Oral Minoxidil didn’t?
Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.
community Switching to Oral from Topical min effective or not
Switching from topical to oral minoxidil may lead to better results for some users, with oral minoxidil generally being more effective due to higher absorption. However, it can also cause side effects like hypertrichosis and blood pressure issues, and individual responses may vary.
community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)
Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.
community How is it possible for someone to be a non responder to ORAL minoxidil?
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