Hair Follicle Sulfotransferase Activity and Effectiveness of Oral Minoxidil in Androgenetic Alopecia

July 2024 in “ Journal of Cosmetic Dermatology ”

Juan Jimenez‐Cauhe, Sergio Vañó‐Galván, Nina Mehta, Ángela Hermosa‐Gelbard, Daniel Ortega‐Quijano, Diego Buendía-Castaño, Diego Fernández‐Nieto, María Librada Porriño‐Bustamante, David Saceda‐Corralo, Cristina Pindado‐Ortega, Óscar M. Moreno‐Arrones, Carlos Gustavo Wambier, Rachita Dhura, Torello Lotti, Andy Goren

minoxidil oral minoxidil androgenetic alopecia hair follicle sulfotransferase SULT activity Rogaine AGA

TLDR Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.

This study examined the link between hair follicle sulfotransferase (SULT) activity and the effectiveness of low-dose oral minoxidil in treating androgenetic alopecia (AGA) in 41 patients (26 males, 15 females) over 6 months. Results showed 63.4% of patients experienced clinical improvement, with males responding better (73.1%) than females (40.0%). Patients with low SULT activity had a significantly higher response rate (85%) compared to those with high SULT activity (42.9%), suggesting that SULT activity in hair follicles may influence the efficacy of oral minoxidil in AGA treatment.

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