Hair Follicle Sulfotransferase Activity and Effectiveness of Oral Minoxidil in Androgenetic Alopecia

    Juan ­Jimenez‐Cauhe, Sergio Vañó‐Galván, Nina Mehta, Ángela Hermosa‐Gelbard, ­Daniel ­Ortega‐Quijano, Diego Buendía-Castaño, Diego Fernández‐Nieto, María Librada Porriño‐Bustamante, David Saceda‐Corralo, Cristina Pindado‐­Ortega, Óscar M. Moreno‐Arrones, Carlos Gustavo Wambier, Rachita Dhura, Torello Lotti, Andy Goren
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    TLDR Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.
    This study examined the link between hair follicle sulfotransferase (SULT) activity and the effectiveness of low-dose oral minoxidil in treating androgenetic alopecia (AGA) in 41 patients (26 males, 15 females) over 6 months. Results showed 63.4% of patients experienced clinical improvement, with males responding better (73.1%) than females (40.0%). Patients with low SULT activity had a significantly higher response rate (85%) compared to those with high SULT activity (42.9%), suggesting that SULT activity in hair follicles may influence the efficacy of oral minoxidil in AGA treatment.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  864 upvotes 4 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community Is microneedling + minoxidil better than oral minoxidil

      in Chat  29 upvotes 4 months ago
      Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  48 upvotes 2 months ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

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      Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

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