Hair Follicle Sulfotransferase Activity and Effectiveness of Oral Minoxidil in Androgenetic Alopecia

    Juan ­Jimenez‐Cauhe, Sergio Vañó‐Galván, Nina Mehta, Ángela Hermosa‐Gelbard, ­Daniel ­Ortega‐Quijano, Diego Buendía-Castaño, Diego Fernández‐Nieto, María Librada Porriño‐Bustamante, David Saceda‐Corralo, Cristina Pindado‐­Ortega, Óscar M. Moreno‐Arrones, Carlos Gustavo Wambier, Rachita Dhura, Torello Lotti, Andy Goren
    Image of study
    TLDR Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.
    This study examined the link between hair follicle sulfotransferase (SULT) activity and the effectiveness of low-dose oral minoxidil in treating androgenetic alopecia (AGA) in 41 patients (26 males, 15 females) over 6 months. Results showed 63.4% of patients experienced clinical improvement, with males responding better (73.1%) than females (40.0%). Patients with low SULT activity had a significantly higher response rate (85%) compared to those with high SULT activity (42.9%), suggesting that SULT activity in hair follicles may influence the efficacy of oral minoxidil in AGA treatment.
    Discuss this study in the Community →

    Research cited in this study

    28 / 28 results

    Related Community Posts Join

    6 / 1000+ results

      community Is microneedling + minoxidil better than oral minoxidil

      in Chat  29 upvotes 3 weeks ago
      Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

      community When are we getting a cure to hair loss?

      in Chat 1 year ago
      Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

      community Tretinoin can make it worse!!!

      in Chat  7 upvotes 1 year ago
      Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

    Related Research

    4 / 4 results