Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness

    Lingfeng Pan, Caihong Li, Philipp Moog, Samuel Knoedler, Haydar Kükrek, Ulf Dornseifer, Hans-Günther Machens, Jun Jiang
    TLDR New biological pathways and potential treatment targets for male pattern baldness were identified.
    This study investigates the molecular basis of male pattern baldness (MPB) using data from 24,069 men in the UK Biobank, identifying 47 proteins associated with MPB severity. The research highlights pathways related to epidermis development, hair cycle regulation, and cell adhesion. Five candidate genes, including CD38, FGF5, TACSTD2, DPEP1, and PLB1, were prioritized, with CD38 being druggable and having low pleiotropic risks. The study provides insights into non-hormonal targets for MPB, offering a framework for developing new therapeutic interventions.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    5 / 1000+ results