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research The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer

108 citations , February 2008 in “The Journal of urology/The journal of urology”

This review discusses the rationale for targeting 5α-reductase isoenzymes in prostate cancer prevention and treatment, highlighting the potential benefits of using inhibitors like dutasteride and finasteride but reports no new experimental results.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

Is There an Association Between 5α-Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature

research Is There an Association between 5a Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature

June 2024 in “Reviews on Recent Clinical Trials”

This review analyzed current research on finasteride and dutasteride and found insufficient evidence to fully elucidate their role in metabolic adverse events, such as liver disease and diabetes, due to a lack of detailed pathophysiologic understanding; further studies are needed to clarify these mechanisms.

Trends in the Development of New Drugs for the Treatment of Benign Prostatic Hyperplasia

research Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia

14 citations , November 2006 in “Current Medicinal Chemistry”

This review discusses recent developments in α1-adrenoceptor antagonists and 5α-reductase inhibitors for treating benign prostatic hyperplasia, reporting no new clinical results while identifying potential areas for future drug development.

research Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates

21 citations , January 2020 in “General and Comparative Endocrinology”

This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.

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community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

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research The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

research Is There an Association between 5a Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature

research Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia

research Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates

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community My understanding of how androgenetic alopecia works (plus FIN and DUT)

community Trying to understand finasteride side effects and post finasteride syndrome

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David Yew, MD

Picasso Jeff

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