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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

Finasteride potentially treats hair loss by reducing DHT production.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Certain drugs that block specific enzymes can help treat prostate diseases.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Dutasteride may help shrink prostate cancer tumors.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride exposure harms tadpole reproduction and hormone balance.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride effectively reduces hair loss by decreasing androgen levels.

Sebocytes play a key role in controlling androgen levels in human skin.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.