Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines

September 2020 in “ OncoTargets and Therapy ”

Dulce Carolina Rodríguez-Lozano, Daniel Velázquez-Vázquez, Aylin Del Moral-Morales, Ignacio Camacho-Arroyo

dihydrotestosterone DHT testosterone 5α-reductase inhibitors finasteride dutasteride Propecia Avodart

TLDR Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

The study from September 2020 explored the impact of dihydrotestosterone (DHT) on human glioblastoma (GBM) cell lines U87 and U251. It found that both DHT and testosterone (T) increased the proliferation, migration, and invasion of these cells, with DHT having a more potent effect. The use of 5α-reductase inhibitors, finasteride (FIN) and dutasteride (D), blocked the effects of T, indicating that the conversion of T to DHT is key in GBM progression. The research suggests that targeting androgen metabolism may be a viable therapeutic approach for GBM treatment. The specific number of samples or participants was not provided in the summary.

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