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    Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

    July 2021 in “ Endocrinology, diabetes & metabolism ”
    J.A. Mondragón, Yesenia Serrano, Andrea Torres … Marta Romano
    Studysummary This study found that glioblastoma cells express key enzymes involved in androgen synthesis, suggesting these enzymes might be potential targets for new therapeutic strategies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase Endocrinology, diabetes & metabolism · 2021
    2. Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines OncoTargets and Therapy · 2020
    3. The Effect of Finasteride and Dutasteride on the Synthesis of Neurosteroids by Glioblastoma Cells Steroids · 2019
    4. Allopregnanolone Promotes Proliferation and Differential Gene Expression in Human Glioblastoma Cells Steroids · 2017
    5. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    6. Structure and Expression of a New Complementary DNA Encoding the Almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-Isomerase in Human Adrenals and Gonads Molecular Endocrinology · 1991