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Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

research Studying the Genetic Predisposing Factors in the Pathogenesis of Acne Vulgaris

39 citations , May 2011 in “Human Immunology”

Genetics play a role in acne, but how exactly they contribute is not fully understood.

research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Molecular Interactions of Natural and Synthetic Steroids in Female Hamsters’ Flank Organs

1 citations , March 2012 in “Journal of Dermatological Science”

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

research Extraskeletal Actions of Vitamin D

119 citations , July 2016 in “Annals of the New York Academy of Sciences”

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

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Community Join

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community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 1 year ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

community Anyone here who’s using Alfatradiol (17a-Estradiol) in consistency with some results?

in Treatment 6 upvotes 4 years ago

User discusses Alfatradiol (17a-Estradiol) as a potential hair loss treatment with mixed results. Concerns include low dosage, receptor theory, and possible increased aromatase activity on scalp.

community I live in the US. Where are most reputable places to purchase either Alfatradiol or Pyralutamide?

in Product 3 upvotes 10 months ago

The user is considering adding Alfatradiol or Pyralutamide to their current hair loss treatment of oral Dutasteride and Minoxidil. They are seeking advice on experiences and purchasing options for these products in the US.

community Alfatradiol is a topical 5AR inhibitor that this study shows is effective in stopping hair loss without sides. It can be bought OTC in Europe right now. Thoughts?

13 upvotes 9 years ago

Hair loss treatments, specifically the use of Alfatradiol as an over-the-counter topical 5AR inhibitor that has been shown to be effective in stopping hair loss without side effects. Other treatments discussed include Minoxidil, finasteride and RU58841.

community Hypothetically, if estradiol has been a "cure" for hair loss, could one apply estradiol topically and just take an estrogen blocker and/or testosterone to offset the systematic effects?

in Research/Science 7 upvotes 5 months ago

Topical estradiol may help with hair loss but can have systemic effects, like reduced testosterone production. Using estrogen blockers can have negative side effects, such as joint pain and reduced sex drive.

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