Follicle Dermal Papilla Cells Undergo Chromatin Remodeling Processes In Vivo And In Vitro
October 2017
in “
Journal of Investigative Dermatology
”
TLDR Hair follicle cells change their DNA packaging during growth cycles and when grown in the lab.
The document discusses a study on the epigenetic changes in dermal papilla (DP) cells of hair follicles, focusing on chromatin remodeling processes both in vivo during the hair follicle cycle and in vitro when the cells are cultured. The study used immunofluorescence to analyze histone methylation markers and the histone-binding protein CBX5, among other markers, in mouse and rat vibrissa follicles. The results showed that histone methylation levels in DP cells varied with the hair follicle cycle, with higher levels in the anagen (growing) phase than in the telogen (resting) phase. A significant change in the expression pattern of heterochromatin versus euchromatin-related markers was observed when DP cells transitioned from in vivo to in vitro culture. The study suggests that these chromatin remodeling processes may have functional implications for the hair follicle cycle and the inductive ability, self-renewal capacity, and differentiation potential of DP cells in vitro.
