Follicle Dermal Papilla Cells Undergo Chromatin Remodeling Processes In Vivo And In Vitro

September 2017 in “ Journal of Investigative Dermatology ”

Elisa Carrasco, Adam Gilmore, Vladimir A. Botchkarev, Colin A.B. Jahoda

dermal papilla cells chromatin remodeling hair follicle cycle histone methylation anagen phase telogen phase heterochromatin euchromatin immunofluorescence CBX5 vibrissa follicles DP cells hair growth phase hair resting phase

TLDR Hair follicle cells change their DNA packaging during growth cycles and when grown in the lab.

The document discusses a study on the epigenetic changes in dermal papilla (DP) cells of hair follicles, focusing on chromatin remodeling processes both in vivo during the hair follicle cycle and in vitro when the cells are cultured. The study used immunofluorescence to analyze histone methylation markers and the histone-binding protein CBX5, among other markers, in mouse and rat vibrissa follicles. The results showed that histone methylation levels in DP cells varied with the hair follicle cycle, with higher levels in the anagen (growing) phase than in the telogen (resting) phase. A significant change in the expression pattern of heterochromatin versus euchromatin-related markers was observed when DP cells transitioned from in vivo to in vitro culture. The study suggests that these chromatin remodeling processes may have functional implications for the hair follicle cycle and the inductive ability, self-renewal capacity, and differentiation potential of DP cells in vitro.

View this study on jidonline.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research 254 Withdrawn

September 2017 in “Journal of Investigative Dermatology”

Aging causes sweat glands to shrink, leading to skin issues, and blue light can help hair grow.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

research An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

23 citations, December 2020 in “Frontiers in Cell and Developmental Biology”

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

research LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

12 citations, August 2020 in “Frontiers in Genetics”

H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations, May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Follicle Dermal Papilla Cells Undergo Chromatin Remodeling Processes In Vivo And In Vitro

Related Community Posts Join

community Hair cloning and injection of dermal papilla cells coming as soon as 2023

community Han Bio claims success at Hair Multiplication

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

community Epibiotech will now offer off-the-shelf allogeneic hair multiplication treatment in South Korea

community Vitamin C and hair growth PH levels