TLDR Aging causes sweat glands to shrink, leading to skin issues, and blue light can help hair grow.
The document contained multiple abstracts related to hair and skin research. One study by T. Ezure and K. Matsuzaki developed a novel 3D imaging method, ASAXA-μCT, which revealed that sweat glands shrink upward with aging, causing dermal defects that lead to decreased skin elasticity, wrinkling, and sagging. Another study by E. Carrasco et al. focused on chromatin remodeling in dermal papilla cells during the hair follicle cycle, finding significant epigenetic changes. S. Buscone et al. investigated the role of photoreceptors in hair growth, showing that blue light stimulates hair growth via CRY1 and OPN3. Lastly, J.M. Ceruti et al. found that bone morphogenetic proteins (BMPs) are critical for hair follicle interactions and that their downregulation by androgens contributes to androgenetic alopecia.
September 2017 in “Journal of Investigative Dermatology” Hair follicle cells change their DNA packaging during growth cycles and when grown in the lab.
1 citations,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
12 citations,
August 2020 in “Frontiers in Genetics” H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.
11 citations,
March 2020 in “Cellular Signalling” XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.
11 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
