Opsins and Cryptochrome Photoreceptors Mediate Blue Light Stimulatory Effect on Hair Growth

September 2017 in “ Journal of Investigative Dermatology ”

Serena Buscone, N. Uzunbajakava, Andrei N. Mardaryev, Natalia V. Botchkareva

blue light hair growth anagen phase hair follicles outer root sheath cells siRNA Cryptochrome 1 Opsin 3 cell proliferation transcriptomic analysis apoptosis CRY1 protein synthesis metabolic activity ORS cells CRY1 OPN3

TLDR Blue light helps hair growth by affecting specific proteins in hair follicle cells.

The document reports on a study that investigated the role of photoreceptors in mediating the effects of blue light on hair growth. The study found that 453 nm blue light at a low radiant exposure of 3.2 J/cm^2 has a positive effect on hair growth by prolonging the anagen phase in hair follicles ex vivo. In vitro experiments with primary outer root sheath (ORS) cells showed that siRNA-mediated inhibition of Cryptochrome 1 (CRY1) or Opsin 3 (OPN3) resulted in reduced cell proliferation. Transcriptomic analysis revealed that knocking down CRY1 or OPN3 altered the expression of genes involved in proliferation and apoptosis. Treatment with blue light stimulated CRY1 protein synthesis and significantly promoted metabolic activity and proliferation of ORS cells, an effect that was negated by OPN3 knockdown. These findings suggest that blue light can stimulate hair growth through interactions with CRY1 and OPN3 photoreceptors.

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research Blue Light Stimulatory Effect on Hair Growth Mediated by Opsin and Cryptochrome Photoreceptors

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blue light can help hair grow by affecting certain receptors in hair follicles.