Opsins and Cryptochrome Photoreceptors Mediate Blue Light Stimulatory Effect on Hair Growth

    September 2017 in “ Journal of Investigative Dermatology ”
    Serena Buscone, N. Uzunbajakava, Andrei N. Mardaryev, Natalia V. Botchkareva
    Image of study
    TLDR Blue light helps hair growth by affecting specific proteins in hair follicle cells.
    The document reports on a study that investigated the role of photoreceptors in mediating the effects of blue light on hair growth. The study found that 453 nm blue light at a low radiant exposure of 3.2 J/cm^2 has a positive effect on hair growth by prolonging the anagen phase in hair follicles ex vivo. In vitro experiments with primary outer root sheath (ORS) cells showed that siRNA-mediated inhibition of Cryptochrome 1 (CRY1) or Opsin 3 (OPN3) resulted in reduced cell proliferation. Transcriptomic analysis revealed that knocking down CRY1 or OPN3 altered the expression of genes involved in proliferation and apoptosis. Treatment with blue light stimulated CRY1 protein synthesis and significantly promoted metabolic activity and proliferation of ORS cells, an effect that was negated by OPN3 knockdown. These findings suggest that blue light can stimulate hair growth through interactions with CRY1 and OPN3 photoreceptors.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 217 results

      community New & Improved Hair Growth Stack for Maximum Results

      in Treatment  2 upvotes 1 month ago
      A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

      community Extreme hair and beard growth from Stemoxydine. Big 3 + 1?

      in Product  23 upvotes 4 years ago
      Using a combination of Stemoxydine, minoxidil, dutasteride, and keto shampoo to achieve extreme hair and beard growth. The user has experienced positive results with terminal hairs at the hairline and an increase in density to their stubble after several weeks of use.

      community So happy with results! 4 months

      in Progress Pictures  115 upvotes 2 months ago
      The conversation is about a user experiencing positive hair regrowth results after using finasteride, minoxidil spray, dermapen, and low-level light therapy (LLLT) for four months. The user recommends using a specific device for LLLT and mentions using the Hims spray for finasteride and minoxidil.

      community Hair Growth Journey: 10 months

      in Progress Pictures  252 upvotes 9 months ago
      A 31-year-old who experienced severe hair loss during medical school tried various treatments, including topical and oral finasteride and minoxidil, but stopped due to side effects. They restarted treatment 10 months ago with a regimen including topical finasteride, minoxidil, retinoic acid, hydrocortisone, oral minoxidil, and light therapy, emphasizing the importance of consistency and skincare.

      community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

      in Satire  726 upvotes 1 year ago
      The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.

    Related Research

    1 / 1 results