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Glossary Depression

persistent sadness and loss of interest affecting daily life

Depression, also known as Major Depressive Disorder (MDD), is a mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities. It can also involve physical symptoms such as changes in sleep, appetite, and energy levels, and can significantly impair daily functioning.

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research Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

173 citations , September 2011 in “Journal of Investigative Dermatology”

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

research Depression, anxiety and perceived stress in women with and without PCOS: a community-based study

85 citations , August 2018 in “Psychological Medicine”

This study reported that women with PCOS had higher levels of depression, anxiety, and perceived stress compared to those without PCOS, with stress potentially mediating these associations.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.

research Putative role for insulin resistance in depression risk in polycystic ovary syndrome

46 citations , June 2015 in “Fertility and Sterility”

This study found that, among women with polycystic ovary syndrome, insulin resistance was significantly associated with an increased risk of depression, even after accounting for factors like BMI.

research Evaluation of affective temperament and anxiety–depression levels of patients with polycystic ovary syndrome

35 citations , July 2015 in “Journal of Affective Disorders”

This study found that women with polycystic ovary syndrome have significantly higher scores for affective temperaments and anxiety and depression than healthy controls, suggesting risk for depressive and anxiety disorders.

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community Regression report from 2017 to 2025

121 upvotes 6 months ago

The user stopped finasteride for family planning but plans to restart it and is considering dutasteride. Users discuss the safety of finasteride during family planning, with some sharing experiences of having healthy children while on the medication.

community Regression? Has anyone experienced this?

in Progress Pictures 46 upvotes 1 year ago

The user is experiencing increased hair shedding and is concerned about regression despite consistent use of finasteride, minoxidil, and other treatments. The consensus is that this is likely a temporary shedding phase, and adjustments to the dermarolling frequency are suggested.

community Still regressing after a few years of dht blockers, what can i add to my stack?

in Progress Pictures 4 upvotes 5 months ago

The user is experiencing hair loss despite using finasteride and dutasteride and is considering adding minoxidil. Suggestions include switching to daily dutasteride and adding a topical anti-androgen.

community Insane regression after hyper-responding (17M) AMA

in Progress Pictures 137 upvotes 1 year ago

A 17-year-old experienced significant hair loss after switching from topical to oral minoxidil and adding finasteride. The recommendation is to return to topical minoxidil and continue with finasteride or consider dutasteride.

community Experiencing Depression on Finasteride 1mg Daily for 6 Months - Advice Needed

in General 65 upvotes 6 months ago

The user is experiencing depression and occasional suicidal thoughts while taking finasteride 1 mg daily for six months and is considering stopping it to see if their mood improves. They are seeking advice from others who may have experienced similar mood changes on finasteride.

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