In this study, increased corticosterone from chronic stress prolonged hairfolliclestemcellquiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
2 citations
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May 2022 in “Stem cell research & therapy”
This study found that hairfolliclestem cells in the hairpoor mouse, a model for Marie-Unna hypotrichosis, lose their quiescent state, leading to a disordered hair cycle and contributing to alopecia.
October 2021 in “Research Square (Research Square)”
This study found that in hairpoor mice, disruptions in hairfolliclestemcellquiescence and signaling pathways lead to disturbed hair cycles, which may help explain alopecia development in Marie-Unna Hypotrichosis patients.
This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hairfolliclestem cells inactive, and its removal leads to hair growth initiation in mice.
Corticosterone inhibits GAS6, affecting hairfolliclestem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.
Relaxation may promote hair growth by reducing corticosterone, which affects hairfolliclestem cells. Corticosteroids are used for alopecia areata, but their long-term use for androgenic alopecia is uncertain.
PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hairfolliclestem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
PP405 is ineffective for miniaturized, fibrosed hairfollicles in androgenetic alopecia. AMP303 may activate hairfolliclestem cells, but minoxidil and finasteride are still the main treatments.
ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hairfollicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.
Can long-term use of Fluocinolone affect the health of hairfollicles?There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.
What do clinical trials say about the safety and effectiveness of SCUBE3 for hair regrowth?No clinical trial of SCUBE3 for hair regrowth has been registered on ClinicalTrials.gov or published, so there is no human safety or effectiveness data. The evidence is limited to one 2022 laboratory and mouse study reporting that SCUBE3 activates hair follicle stem cells through TGF-beta signalling.