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GlossaryProcyanidin

type of plant compound with antioxidant and hair growth benefits

Procyanidin is a type of flavonoid found in various plants, including apples, grapes, and cocoa. It has antioxidant properties and has been studied for its potential health benefits, including promoting hair growth by stimulating hair follicles and improving blood circulation to the scalp.

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Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

79 citations, March 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

Procyanidin compounds from grape seeds were found to significantly increase mouse hair growth.

research Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study

37 citations, January 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

Apple extract called procyanidin B-2 was found to greatly increase hair growth.

Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1

research Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1

36 citations, December 2002 in “Experimental dermatology”

Barley extract, specifically procyanidin B-3, can promote hair growth and counteract growth inhibition.

research Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent

32 citations, December 2000 in “Phytomedicine”

Apple-derived procyanidin B-2 can safely promote hair growth in men.

research Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth

32 citations, January 2000 in “Skin pharmacology and physiology”

Certain substances that block a specific protein help promote hair growth.

research Toxicological Studies on Procyanidin B-2 for External Application as a Hair Growing Agent

30 citations, May 1999 in “Food and chemical toxicology”

Procyanidin B-2 is safe to use on skin as a hair growth product.

Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

research Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

28 citations, December 2005 in “Journal of cosmetic dermatology”

Apple procyanidin applied to the scalp may help grow hair without side effects.

research The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent

26 citations, June 2001 in “PTR. Phytotherapy research/Phytotherapy research”

Procyanidin B-2 lotion might help men grow thicker hair without side effects.

research Procyanidins Attenuate Neuropathic Pain by Suppressing Matrix Metalloproteinase-9/2

22 citations, June 2018 in “Journal of Neuroinflammation”

Procyanidins from grape seeds reduce nerve pain by blocking specific proteins and inflammation.

research Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms

14 citations, January 2006 in “Skin pharmacology and physiology”

Procyanidin compounds from apples and barley promote hair growth and prevent hair cell death.

research African Baobab (Adansonia Digitata) Fruit as a Promising Source of Procyanidins

5 citations, February 2020 in “European Food Research and Technology”

African baobab fruit is a good source of antioxidants and micronutrients, but too much can cause laxative effects.

research Procyanidin B-2 and the Hair-Growing Activity of Proanthocyanidins

1 citations, January 2001 in “Cosmetics and toiletries”

Procyanidin B-2 from apple juice significantly increases hair growth and may be more effective than minoxidil without side effects.

research Progress on Study of Pharmacological Effects of Procyanidins

1 citations, March 2009 in “China Journal of Chinese Matera Medica”

Procyanidins may have antioxidant, heart health, cancer-fighting, anti-inflammatory, anti-diabetic, liver-protective, and other health benefits with high efficiency and low toxicity.

research Studies on the Biological Actions of Procyanidins and Phosphatidic Acids on Hair Follicles: Experimental Approaches

January 2006

Procyanidins and phosphatidic acids help promote hair growth.

Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study

research Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study

January 2022 in “Turk Dermatoloji Dergisi”

Topical procyanidin B2 significantly increases hair count and is a safe treatment for male pattern baldness.

Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

research Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

282 citations, April 2007 in “Journal of Agricultural and Food Chemistry”

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

research Biological Actions of Oligomeric Procyanidins: Proliferation of Epithelial Cells and Hair Follicle Growth

8 citations, January 2001 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Oligomeric procyanidins may help hair grow by affecting cell growth and the hair growth cycle.

research A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention

13 citations, May 2019 in “Cancer Prevention Research”

Grape seed extract may safely and effectively help prevent lung cancer.

research Studies on a Hair Growth Stimulant, Procyanidin B-2

January 2002

A Semisynthetic Approach for the Simultaneous Reaction of Grape Seed Polymeric Procyanidins with Catechin and Epicatechin to Obtain Oligomeric Procyanidins in Large Scale

research A Semisynthetic Approach for the Simultaneous Reaction of Grape Seed Polymeric Procyanidins with Catechin and Epicatechin to Obtain Oligomeric Procyanidins in Large Scale

9 citations, April 2019 in “Food Chemistry”

Created large amounts of grape seed compounds using a new method.

Early Plant Growth and Biochemical Responses Induced by Azospirillum Brasilense Sp245 Lipopolysaccharides in Wheat (Triticum Aestivum L.) Seedlings Are Attenuated by Procyanidin B2

research Early Plant Growth and Biochemical Responses Induced by Azospirillum Brasilense Sp245 Lipopolysaccharides in Wheat (Triticum Aestivum L.) Seedlings Are Attenuated by Procyanidin B2

11 citations, March 2018 in “Protoplasma”

Lipopolysaccharides boost wheat seedling growth, but procyanidin B2 weakens this effect.

research Effect of Procyanidin Oligomers on Oxidative Hair Damage

10 citations, January 2011 in “Skin research and technology”

Procyanidin oligomers can protect hair from oxidative damage and could be good for hair care products.

research Natural Products for Male Androgenetic Alopecia

2 citations, January 2022 in “Dermatologic Therapy”

Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.

research Multifunctional DNA Hydrogels with Hydrocolloid-Cotton Structure for Regeneration of Diabetic Infectious Wounds

83 citations, September 2021 in “Advanced functional materials”

The DNA hydrogel helps heal diabetic wounds by absorbing fluids, warming, sticking to tissue, killing bacteria, and aiding tissue and hair regrowth.

research Therapeutic Strategies for Treating Hair Loss

42 citations, March 2006 in “Drug Discovery Today: Therapeutic Strategies”

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations, August 2018 in “Skin appendage disorders”

Some alternative treatments for hair loss might work, but more research is needed.

research Polyphenols from the Heartwood of Cercidiphyllum Japonicum and Their Effects on Proliferation of Mouse Hair Epithelial Cells

26 citations, November 2002 in “Planta medica”

Extracts from Cercidiphyllum japonicum wood can stimulate mouse hair cell growth like common hair growth treatments.