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GlossarySMAD signaling

cellular process transmitting signals from surface to nucleus

SMAD signaling, also known as the SMAD pathway, is a cellular process that transmits signals from the cell surface to the nucleus in response to transforming growth factor-beta (TGF-β) and related cytokines. This pathway involves SMAD proteins, which are activated by receptor kinases and then move into the nucleus to regulate gene expression. This signaling is crucial for various biological processes, including cell growth, differentiation, and development, and has implications in conditions like cancer and fibrosis.

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research Live Imaging of Smad2/3 Signaling in Mouse Skin Wound Healing

12 citations, September 2007 in “Wound repair and regeneration”

Smad2/3-dependent TGF-β signaling increases during wound healing.

research All-Trans-Retinoic Acid Inhibits Mink Hair Follicle Growth by Inhibiting Proliferation and Inducing Apoptosis of Dermal Papilla Cells Through TGF-β2/Smad2/3 Pathway

10 citations, August 2020 in “Acta histochemica”

All-trans-retinoic acid stops mink hair growth by affecting cell growth and causing cell death.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations, January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades

research Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades

14 citations, January 2016 in “Biochemical and Biophysical Research Communications”

Ginsenoside Re from ginseng may help hair grow by blocking a specific growth-inhibiting pathway.

research Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome

October 2023 in “Frontiers in endocrinology”

Effective PCOS treatments require targeting specific signaling pathways.

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community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 8 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community What's your option on complementary treatment

in Product 3 upvotes 5 months ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.