TLDR GPR39 is linked to certain cells in the sebaceous gland and helps with skin healing.
The document describes a study that identified G protein-coupled receptor 39 (GPR39) as a marker for a specific cell population within the sebaceous gland of mice, which is associated with SG stem cells. GPR39 was found to be expressed in cells at the SG opening and played a role in skin wound healing, particularly during the intermediate stage, although it was not essential for skin development and homeostasis. The absence of GPR39 resulted in delayed wound healing. The study suggests GPR39 as a potential target for skin repair therapies, despite it not being a key regulator in SGs. GPR39-mutant mice showed impaired wound closure, indicating its association with cell proliferation and migration during healing. The exact number of mice used was not provided.
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479 citations
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June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
56 citations
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September 2013 in “Experimental Dermatology” The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.
238 citations
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April 2013 in “Development” Fat cells help recruit healing cells and build skin structure during wound healing.
107 citations
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October 2012 in “Seminars in Cell & Developmental Biology” The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
265 citations
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July 2012 in “Cell” The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.
835 citations
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
170 citations
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May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.
