GPR39 Marks Specific Cells Within the Sebaceous Gland and Contributes to Skin Wound Healing

The document describes a study that identified G protein-coupled receptor 39 (GPR39) as a marker for a specific cell population within the sebaceous gland of mice, which is associated with SG stem cells. GPR39 was found to be expressed in cells at the SG opening and played a role in skin wound healing, particularly during the intermediate stage, although it was not essential for skin development and homeostasis. The absence of GPR39 resulted in delayed wound healing. The study suggests GPR39 as a potential target for skin repair therapies, despite it not being a key regulator in SGs. GPR39-mutant mice showed impaired wound closure, indicating its association with cell proliferation and migration during healing. The exact number of mice used was not provided.