TLDR GPR39 is linked to certain cells in the sebaceous gland and helps with skin healing.
The document describes a study that identified G protein-coupled receptor 39 (GPR39) as a marker for a specific cell population within the sebaceous gland of mice, which is associated with SG stem cells. GPR39 was found to be expressed in cells at the SG opening and played a role in skin wound healing, particularly during the intermediate stage, although it was not essential for skin development and homeostasis. The absence of GPR39 resulted in delayed wound healing. The study suggests GPR39 as a potential target for skin repair therapies, despite it not being a key regulator in SGs. GPR39-mutant mice showed impaired wound closure, indicating its association with cell proliferation and migration during healing. The exact number of mice used was not provided.
479 citations
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June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
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September 2013 in “Experimental Dermatology” The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.
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March 2013 in “Development” Fat cells help recruit healing cells and build skin structure during wound healing.
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August 2012 in “Seminars in Cell & Developmental Biology” The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
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July 2012 in “Cell” The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
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November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.
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November 2005 in “Nature Medicine”
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
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June 2016 in “Cell Transplantation” Sebaceous glands can help harvest hair follicle stem cells to regenerate skin and hair.
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November 2022 in “Frontiers in immunology” Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
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July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.
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July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
