18 citations,
January 1998
in “Endocrine”
RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.
10 citations,
November 1997
in “British Journal of Dermatology”
RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.
1 citations,
January 1997
in “Journal of Investigative Dermatology”
RU58841, an androgen receptor blocker, significantly increased hair density, thickness, and length in monkeys when applied topically daily for several months.
1 citations,
January 1995
in “Journal of Investigative Dermatology”
RU58841, a substance from France, can potentially block the effects of hormones that cause hair loss and excessive hair growth, performing better than a similar substance, cyproterone acetate.
26 citations,
January 2005
in “PubMed”
49 citations,
January 1994
in “The Journal of Steroid Biochemistry and Molecular Biology”
RU 58841 may treat acne, hair loss, and excessive hair growth.
March 1998
in “Journal of Dermatological Science”
Combining RU58841 and minoxidil significantly increases hair growth.
4 citations,
January 2014
in “RSC Advances”
A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
9 citations,
November 1997
in “British Journal of Dermatology”
December 2012
in “http://isrctn.org/>”
December 2012
in “http://isrctn.org/>”
18 citations,
April 2001
in “Bioorganic & Medicinal Chemistry Letters”
The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.
20 citations,
December 1995
in “International Journal of Pharmaceutics”
Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.
16 citations,
October 1994
in “The Journal of Steroid Biochemistry and Molecular Biology”
Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
62 citations,
May 1997
in “Journal of Pharmaceutical Sciences”
Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.
19 citations,
January 1997
in “Endocrinology”
Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.
6 citations,
November 2004
in “Bioorganic & Medicinal Chemistry Letters”
Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.
3 citations,
April 2005
in “Expert Opinion on Investigational Drugs”
New treatments for hair loss are being developed using molecular biology.
1 citations,
May 2001
in “Journal of Labelled Compounds and Radiopharmaceuticals”
Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.
33 citations,
January 1997
in “Endocrinology”
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
December 2015
in “Vestnik dermatologii i venerologii”
People with hair loss have different hormone levels, and these hormones can affect hair growth.
May 2023
in “Vestnik dermatologii i venerologii”
Early-stage male pattern baldness shows two types of hair loss: one on the top of the head linked to hormonal changes, and another at the back of the head. The top hair loss responds well to specific treatment, while the back hair loss does not.
January 2023
in “Klinicheskaya dermatologiya i venerologiya”
January 2022
in “Klinicheskaya dermatologiya i venerologiya”
Trichoscopy can diagnose hair loss by looking for common signs like uneven hair thickness, "yellow dots," and more thin hairs, which are found in both men and women.
December 2021
in “Digital Doctor”
December 2021
in “Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk”
September 2021
in “Conference Proceedings”
Older men with high total testosterone might not show symptoms, while younger men with hyperandrogenism may experience hair loss or acne.
August 2021
in “Consilium medicum”
December 2020
in “Vestnik dermatologii i venerologii”
Iron supplements and physiotherapy together can better treat hair loss in women with iron deficiency.
November 2020
in “Дерматовенерология, косметология”
