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    Glossary RU58841

    non-steroidal anti-androgen researched for treating androgenic alopecia

    RU58841 is a non-steroidal anti-androgen that is often researched for its potential to treat androgenic alopecia (pattern hair loss). It works by binding to androgen receptors in the scalp, thereby preventing dihydrotestosterone (DHT) from attaching to these receptors and causing hair follicle miniaturization.

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    Research 30 of 825

    1. RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 49 citations
    2. RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia. PubMed · 2005 · 26 citations
    3. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice British Journal of Dermatology · 1997 · 10 citations
    4. Alternative synthesis of the anti-baldness compound RU58841 RSC Advances · 2014 · 4 citations
    5. Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque. Journal of Investigative Dermatology · 1997 · 1 citations
    6. Significance of RU58841 as a therapeutic agent effecting androgen receptor molecular interactions in human hair follicles. Journal of Investigative Dermatology · 1995 · 1 citations
    7. Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans Biomedical Chromatography · 2026
    8. Microneedle-Mediated Delivery of Ru Nanozyme–Magnesium Silicate Nanosheets Restores Redox and Regenerative Balance in Irradiated Skin Interdisciplinary Research in Medical Sciences Specialty · 2025
    9. The effect of topical RU58841 (androgen receptor blocker) combined with minoxidil on hair growth in macaque androgenetic alopecia Journal of Dermatological Science · 1998
    10. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice British Journal of Dermatology · 1997 · 9 citations
    11. A multi-centre, double-blind, randomised, vehicle-controlled study for a quantitative estimation of hair re-growth in male subjects with androgenetic alopecia treated over 6 month with two ethanolic PSK 3841 solutions (2.5% and 5%) 2012
    12. A double blind, randomised, vehicle-controlled, safety and tolerance study of topical PSK 3841 solution at 5% administered twice daily over four weeks to healthy Caucasian males with androgenetic alopecia 2012
    13. Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes Journal of Pharmaceutical Sciences · 1997 · 62 citations
    14. Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism 2018 · 38 citations
    15. Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque<sup>1</sup> Endocrinology · 1997 · 33 citations
    16. Percutaneous absorption of a new antiandrogen included in liposomes or in solution International Journal of Pharmaceutics · 1995 · 20 citations
    17. CLINICAL UPDATES IN HAIR Dermatologic Clinics · 1997 · 19 citations
    18. Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque Endocrinology · 1997 · 19 citations
    19. Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands Bioorganic & Medicinal Chemistry Letters · 2001 · 18 citations
    20. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    21. Alopecia - the search for novel agents continues Expert Opinion on Therapeutic Patents · 1997 · 11 citations
    22. &lt;i&gt;In-Vitro&lt;/i&gt; Effect of Sex Steroids on Mouse Melanoma (B16F10) Cell Growth CellBio · 2014 · 11 citations
    23. Synthesis and structure–activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands Bioorganic & Medicinal Chemistry Letters · 2004 · 6 citations
    24. Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance Dermatologic Clinics · 2007 · 4 citations
    25. Investigational medications in the treatment of alopecia Expert Opinion on Investigational Drugs · 2005 · 3 citations
    26. Development of radioiodinated nonsteroidal androgen receptor ligands for spect imaging of prostate cancer Journal of Labelled Compounds and Radiopharmaceuticals · 2001 · 1 citations
    27. Sex hormones and related compounds, including hormonal contraceptives Side effects of drugs annual · 2014
    28. Circumventing Mukaiyama oxidation: selective S–O bond formation via sulfenamide–alcohol coupling Beilstein Journal of Organic Chemistry · 2026
    29. Trained Immunity and Local Innate Immune Memory in the Lung Cell · 2018 · 77 citations
    30. Interventions for nail psoriasis Cochrane library · 2013 · 65 citations