Dose-Dependent and Long-Term Effects of RU58841 (Androgen Receptor Blocker) on Hair Growth in the Bald Stumptailed Macaque

January 1997 in “ Journal of Investigative Dermatology ”

Ellen K. Bayne, J. Randall Flanagan, B. Azzolina, Mark H. Einstein, R. Mumford, Julia Ayala, B. S. Chang, Diane Thiboutot, Irwin L. Singer, Gerald F. Harris

RU58841 androgen receptor blocker androgenetic alopecia hair density hair thickness hair length folliculogram terminal size follicles anagen phase RU58841 androgen receptor blocker male pattern baldness hair density hair thickness hair length follicle analysis terminal size follicles growth phase

TLDR RU58841, an androgen receptor blocker, significantly increased hair density, thickness, and length in monkeys when applied topically daily for several months.

In a study conducted 26 years ago, the effects of RU58841, an androgen receptor blocker, on hair growth were examined using the macaque model of androgenetic alopecia. The study involved 4 to 5 monkeys in each group, with solutions of RU58841 (5%, 3%, 1%, and 0.5%) and a vehicle applied topically once per day for 6 months. Three monkeys in the 5%, 0.5% and vehicle groups were treated for 12 to 24 months to observe long-term effects. The results showed a significant increase in hair density, thickness, and length in all cases of the 5% group as early as 3 months after treatment. By the fifth month, folliculogram analysis revealed an average two- to threefold increase in the population of follicles enlarged to terminal size and in the anagen phase compared to the control group.

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research The Effect of Topical RU58841 (Androgen Receptor Blocker) Combined with Minoxidil on Hair Growth in Macaque Androgenetic Alopecia

March 1998 in “Journal of Dermatological Science”

Combining RU58841 and minoxidil significantly increases hair growth.