An Outline of SARS-CoV-2 Pathogenesis and the Complement Cascade of Immune System

The document outlined the pathogenesis of SARS-CoV-2 and its interaction with the immune system, emphasizing the rapid human-to-human transmission and the global spread of the virus. It highlighted the importance of understanding the virus's transmission and pathophysiological properties to aid in developing therapeutic molecules and antiviral drugs. The review discussed how the virus exploits host machinery and the potential severity caused by an overactive immune response. While safe and effective vaccines were seen as crucial tools, the document stressed the continued importance of preventive measures like mask-wearing, handwashing, and physical distancing to reduce transmission. Research was ongoing to understand how vaccines protect against both disease and transmission.