Spiking Dependence of SARS-CoV-2 Pathogenicity on TMPRSS2

February 2021 in “ Journal of Medical Virology ”

Asim Z. Abbasi, Dania A. Kiyani, Syeda M. Hamid, Muhammad Saalim, Ammad Fahim, Nasir Jalal

TLDR TMPRSS2 affects COVID-19 severity and treatment options.

This review explored the role of the Transmembrane Serine Protease 2 (TMPRSS2) in influencing the susceptibility and pathogenicity of SARS-CoV-2 across different population groups. It highlighted that the cleavage of the viral spike protein by TMPRSS2 is crucial for viral entry into host cells, and variations in the expression of the TMPRSS2 gene among ethnic groups could impact COVID-19 infection rates and outcomes. The review also discussed potential treatments involving TMPRSS2 protease blockers and inhibitors as promising strategies for managing COVID-19.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Spiking Dependence of SARS-CoV-2 Pathogenicity on TMPRSS2

30 citations , February 2021 in “Journal of Medical Virology”

TMPRSS2 affects COVID-19 severity and treatment options.

research Sex Differences in SARS-CoV-2 Infection Rates and the Potential Link to Prostate Cancer

113 citations , July 2020 in “Communications biology”

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

research A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

134 citations , April 2020 in “Journal of Cosmetic Dermatology”

Male pattern hair loss could hint at androgens affecting COVID-19 severity.