ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-CoV-2 in Cancer Patients

    January 2020 in “ Cell Transplantation ”
    Sara Ravaioli, Michela Tebaldi, Eugenio Fonzi, Davide Angeli, Massimiliano Mazza, Fabio Nicolini, Alessandro Lucchesi, Francesca Fanini, Francesca Pirini, Maria Maddalena Tumedei, Claudio Cerchione, Pierluigi Viale, Vittorio Sambri, Giovanni Martinelli, Sara Bravaccini
    TLDR Targeting ACE2 and TMPRSS2 may help prevent or treat COVID-19 in cancer patients.
    The study investigated the expression and genetic variants of ACE2 and TMPRSS2 to understand genetic susceptibility to SARS-CoV-2 in cancer patients. It found that ACE2 and TMPRSS2 expressions were higher in tumors from males and elderly patients, suggesting increased vulnerability to the virus. Certain genetic variants, such as S19P in Africans and E37K in Finnish males, might affect viral interaction. The research suggested that targeting these proteins could be beneficial for preventive and therapeutic purposes, especially in cancer patients, and highlighted the potential of anti-androgen therapy in reducing susceptibility in prostate cancer patients. However, further research was needed to establish a direct correlation between gene expression and COVID-19 incidence in these patients.
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