TLDR ERG increases SOX9, promoting prostate cancer growth and invasion.
The study investigated the role of ERG in androgen receptor (AR)-mediated regulation of SOX9 in prostate cancer (PCa). Researchers found that ERG, expressed from the TMPRSS2:ERG fusion gene, enhanced AR signaling, leading to increased SOX9 expression, which was linked to tumor invasion and growth. This mechanism was specific to TMPRSS2:ERG fusion-positive PCa cells. SOX9 overexpression resulted in neoplasia and stimulated tumor invasion, while SOX9 depletion impaired these processes. The study concluded that SOX9 is a critical downstream effector of ERG in fusion-positive PCa, suggesting potential therapeutic targets for managing the disease.
1 citations,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
40 citations,
September 2019 in “Molecular and Cellular Endocrinology” Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.
46 citations,
June 2015 in “Journal of Investigative Dermatology” Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.
139 citations,
December 2020 in “Cell Stem Cell” Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
89 citations,
August 2013 in “PloS one” Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.
