TLDR Androgen receptor overexpression can increase prostate cancer cell growth even without hormones.
The study investigated the effects of androgen receptor (AR) overexpression in prostate cancer, focusing on cell proliferation and AR translocation to the nucleus. Using two AR overexpressing and two control LNCaP derived cell strains, the research found that AR overexpression led to increased proliferation, especially in 10 nM DHT and 1 nM R1881 conditions, and sustained proliferation even in starvation conditions. The AR translocation to the nucleus occurred within an hour and was more efficient in overexpressing strains, correlating with AR expression levels. These findings suggested that AR overexpression enhanced cell proliferation and nuclear translocation efficiency, contributing to the progression of prostate cancer.
59 citations
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April 2016 in “Breast Cancer Research and Treatment” Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.
2 citations
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November 2017 in “Elsevier eBooks” Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.
26 citations
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May 2012 in “Cellular and Molecular Life Sciences” NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.
35 citations
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January 2012 in “The Journal of Sexual Medicine” Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.
82 citations
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February 1989 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.
59 citations
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May 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
