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GlossaryMineralocorticoids

hormones that regulate electrolyte and fluid balance in kidneys

Mineralocorticoids are a type of hormone produced by the adrenal glands, which are located on top of the kidneys. These hormones, such as aldosterone, help regulate the balance of minerals like sodium and potassium in the body, which in turn controls blood pressure and fluid balance. For professionals, it's important to note that mineralocorticoids act primarily on the distal tubules and collecting ducts of the nephron in the kidneys, influencing electrolyte and water reabsorption.

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powerful topical and oral anti-androgen used mostly by women

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Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations, August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

research The Mineralocorticoid Receptor as a Novel Player in Skin Biology: Beyond the Renal Horizon?

40 citations, November 2009 in “Experimental Dermatology”

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

9 citations, June 2021 in “International Journal of Pharmaceutics”

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

research Mineralocorticoid Receptor Antagonists: A New Sprinkle of Salt and Youth

8 citations, October 2016 in “Journal of Investigative Dermatology”

MR antagonists may improve skin health and wound healing, especially in aging.

research A Novel Actor in Skin Biology: The Mineralocorticoid Receptor

7 citations, October 2015 in “Experimental dermatology”

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

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community Group Buy for MR antagonist finerenone

in Product 11 upvotes 1 year ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community Topical spironolactone - anti androgen

in Research/Science 9 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community When someone posts a scalp tension theory

in Satire 267 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.