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GlossaryMineralocorticoids

hormones that regulate electrolyte and fluid balance in kidneys

Mineralocorticoids are a type of hormone produced by the adrenal glands, which are located on top of the kidneys. These hormones, such as aldosterone, help regulate the balance of minerals like sodium and potassium in the body, which in turn controls blood pressure and fluid balance. For professionals, it's important to note that mineralocorticoids act primarily on the distal tubules and collecting ducts of the nephron in the kidneys, influencing electrolyte and water reabsorption.

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Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations, August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

research The Mineralocorticoid Receptor as a Novel Player in Skin Biology: Beyond the Renal Horizon?

40 citations, November 2009 in “Experimental Dermatology”

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

9 citations, June 2021 in “International Journal of Pharmaceutics”

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

research Mineralocorticoid Receptor Antagonists: A New Sprinkle of Salt and Youth

8 citations, October 2016 in “Journal of Investigative Dermatology”

MR antagonists may improve skin health and wound healing, especially in aging.

research A Novel Actor in Skin Biology: The Mineralocorticoid Receptor

7 citations, October 2015 in “Experimental dermatology”

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

research Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth Ex Vivo

1 citations, January 2019 in “Skin Pharmacology and Physiology”

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

research Faculty Opinions Recommendation of Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

August 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Overexpression of a specific receptor in mice skin causes skin thinning, early skin barrier formation, eye issues, and hair loss.

research Glucocorticoids and Mineralocorticoids in Hair: Facilitating Accurate Diagnosis of Adrenal-Related Endocrine Disorders

November 2024 in “Frontiers in Endocrinology”

Hair analysis can help diagnose adrenal disorders non-invasively.

research Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults: Latest Therapeutic Developments

7 citations, December 2011 in “InTech eBooks”

Glucocorticoid and mineralocorticoid therapy effectively manage Congenital Adrenal Hyperplasia symptoms but have limitations.

research Pharmacology of Different Progestogens: The Special Case of Drospirenone

104 citations, January 2005 in “Climacteric”

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

research Congenital Adrenal Hyperplasia: A Comprehensive Review

88 citations, April 2017 in “Journal of Pediatric and Adolescent Gynecology”

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management

47 citations, February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

research Adrenal Disorders and the Pediatric Brain: Pathophysiological Considerations and Clinical Implications

38 citations, January 2014 in “International Journal of Endocrinology”

Adrenal disorders can cause lasting brain and behavior issues in children.

research Association of Androgenetic Alopecia and Hypertension

34 citations, May 2007 in “PubMed”

Balding in men is strongly linked to high blood pressure and family history.

research Management of Congenital Adrenal Hyperplasia During Pregnancy

29 citations, December 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity”

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

research The Role of the Adrenal Glands in Regulating Onset of Winter Fur Growth in Mink (Mustela Vison)

16 citations, July 1992 in “The journal of experimental zoology/Journal of experimental zoology”

Adrenal glands delay the start of winter fur growth in mink.

research Oral Medications for Central Serous Chorioretinopathy: A Literature Review

14 citations, September 2019 in “Eye”

Some oral medications may help treat central serous chorioretinopathy, especially eplerenone, but more research is needed.

research Current Therapeutic Approaches to Chronic Central Serous Chorioretinopathy

13 citations, February 2019 in “Türk oftalmoloji dergisi”

New treatments for chronic central serous chorioretinopathy show promise in preventing permanent vision loss.

research Roles of Steroid Receptors in the Lung and COVID-19

9 citations, July 2021 in “Essays in Biochemistry”

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance

4 citations, October 2007 in “Dermatologic Clinics”

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

research Steroid Hormones: Overview and Medical Applications

3 citations, January 2016 in “Elsevier eBooks”

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

research Spironolactone

February 2024 in “Practical Diabetes”

Spironolactone helps reduce hospital visits and death from heart issues, lowers blood pressure, but has unclear effects on heart failure with normal heart pump function and can cause high potassium and breast enlargement in men.

research A Case of Glucocorticoid Resistance Syndrome

November 2022 in “Journal of the Endocrine Society”

The patient likely has Chrousos syndrome, a rare condition causing insensitivity to glucocorticoids, requiring high-dose dexamethasone treatment.

research The Glucocorticoid Resistance Syndrome: Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene

December 2023 in “JCEM case reports”

A new gene variant causes glucocorticoid resistance in a mother and son.

research Effects of Natural Products on Skin Inflammation Caused by Abnormal Hormones Secreted by the Adrenal Gland

2 citations, May 2023 in “Frontiers in Pharmacology”

Natural products may help treat skin inflammation from abnormal adrenal hormones.

research Topical Spironolactone in the Treatment of Evaporative Dry Eye Disease

1 citations, June 2023 in “Cureus”

Spironolactone may help improve symptoms and tear quality in dry eye disease.

research Profile of the Progesterone Derivative Chlormadinone Acetate: Pharmacodynamic Properties and Therapeutic Applications

33 citations, January 2009 in “Contraception”

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.