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    GlossaryEstrogen Receptor Antagonist (ER Antagonist)

    blocks estrogen from activating its cellular receptors

    An Estrogen Receptor Antagonist, also known as an Estrogen Blocker or ER Antagonist, is a substance that binds to estrogen receptors on cells and prevents estrogen from exerting its effects. This can be useful in treating conditions like hormone-sensitive cancers, such as certain types of breast cancer, by inhibiting the growth-promoting effects of estrogen on these cancer cells.

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      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  732 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Update: Chest discomfort from RU58841

      in Update  34 upvotes 9 months ago
      A user experienced severe chest pains and shortness of breath after using RU58841 for hair loss and was advised by a doctor that blocking androgens can weaken the heart. They decided to continue with finasteride, minoxidil, and a hair transplant instead.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 7 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

      community Big sheeding after 9 months on minoxidil. Maybe caused by switching brands?

      in Minoxidil  135 upvotes 11 months ago
      A user experienced significant hair regrowth using Minoxidil but started shedding hair after switching brands and adding treatments like Topical Finasteride and microneedling. They also faced increased hair loss after using Ketoconazole shampoo and are seeking advice on whether brand switching or the shampoo could be the cause.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 1 year ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.