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GlossaryEstrogen Receptor Antagonist (ER Antagonist)

blocks estrogen from activating its cellular receptors

An Estrogen Receptor Antagonist, also known as an Estrogen Blocker or ER Antagonist, is a substance that binds to estrogen receptors on cells and prevents estrogen from exerting its effects. This can be useful in treating conditions like hormone-sensitive cancers, such as certain types of breast cancer, by inhibiting the growth-promoting effects of estrogen on these cancer cells.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Update: Chest discomfort from RU58841

in Update 35 upvotes 10 months ago

A user experienced severe chest pains and shortness of breath after using RU58841 for hair loss and was advised by a doctor that blocking androgens can weaken the heart. They decided to continue with finasteride, minoxidil, and a hair transplant instead.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 8 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Big sheeding after 9 months on minoxidil. Maybe caused by switching brands?

in Minoxidil 133 upvotes 1 year ago

A user experienced significant hair regrowth using Minoxidil but started shedding hair after switching brands and adding treatments like Topical Finasteride and microneedling. They also faced increased hair loss after using Ketoconazole shampoo and are seeking advice on whether brand switching or the shampoo could be the cause.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 1 year ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 10 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community ~5 months topical minoxidil + oral finasteride results (swipe images). Slacked with minoxidil this past month, trying to wean off anyways. My last update because I’m hopping off fin and switching to RU in a few weeks (nothing to do with fin efficacy, just experimenting).

in Progress Pictures 145 upvotes 4 years ago

The user experienced significant hair thickening after using topical minoxidil and oral finasteride for about 5 months and is considering switching from finasteride to RU58841. Other users encourage the original poster to continue the current treatment due to the positive results.

community Would there be ANY reason to still take 5AR inhibitors if pyrilutamide does what is intended?

in Research/Science 19 upvotes 2 years ago

A potential new treatment for hair loss, Pyrilutamide, and the discussion of whether or not people should still be taking traditional treatments like Minoxidil and Finasteride with it.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 60 upvotes 5 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 6 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Why the fu*k do people behave like this?

in Chat 385 upvotes 1 year ago

People making comments on others' hair loss, and the different strategies used to deal with it. Treatments mentioned include finasteride and minoxidil.

community Anyone here who’s using Alfatradiol (17a-Estradiol) in consistency with some results?

in Treatment 8 upvotes 3 years ago

User discusses Alfatradiol (17a-Estradiol) as a potential hair loss treatment with mixed results. Concerns include low dosage, receptor theory, and possible increased aromatase activity on scalp.

community 4 Months on Minoxidil Foam, 3 months on Redensyl (no longer using)

in Progress Pictures 12 upvotes 4 years ago

A 24 year old man suffering from male pattern baldness who has been using minoxidil foam and Redensyl (no longer using) for four months, resulting in general thickening of the hair with some regrowth. The user is also awaiting to get a Finasteride prescription and hormone panel done.

community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

in Minoxidil 178 upvotes 1 month ago

Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 21 upvotes 3 months ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Help in Germany to get recommended medicine

in Finasteride/Dutasteride 5 upvotes 4 months ago

A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

community 6 months on fin 1mg everyday, good progress? (20M)

in Is this regrowth? 181 upvotes 5 months ago

A user shared their 6-month progress on finasteride but stopped due to financial issues, seeking advice on whether to continue. Replies strongly advised resuming finasteride to maintain progress, with suggestions for affordable options.

community Anyone know this Dut brand? Just got my prescription in EU

in Finasteride/Dutasteride 16 upvotes 6 months ago

A user received a prescription for Dutasteride 0.5 in Europe and asked about the brand. Replies confirmed the brand's quality and suggested using the cheapest gelatin capsule form.

community Just to show you the superiority of dutasteride over finasteride (it's huge)

in Research/Science 58 upvotes 6 months ago

Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 7 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Hair energiser tablets, useful or not?

in Product 8 months ago

A user is unsure if "Hair Energiser" tablets are effective for hair growth after a year of use. Replies suggest using finasteride instead and call the tablets a scam.

community 9 month update. I had 4 different people tell me my hair looks good over Christmas break

in Progress Pictures 97 upvotes 11 months ago

The user reported positive feedback on hair appearance after switching from topical to oral minoxidil and finasteride, with no side effects. The treatment includes 1.1mg finasteride, 3mg minoxidil, biotin, and vitamins B5, B6, and C daily.

community What an amazing time to be alive

in Finasteride/Dutasteride 183 upvotes 1 year ago

The post discusses a user's experience with hair loss treatments, specifically topical finasteride, minoxidil, and micro-needling, and their plan to switch to oral versions and add Dutasteride. The conversation includes various responses, with some users sharing their own experiences and side effects, and others expressing desire for a more permanent hair loss solution.

community Ashton Kutcher talked about on the tonight show how he was quitting dut. Looks like the Norwood reaper has already come to collect.

in Satire 623 upvotes 1 year ago

The conversation is about Ashton Kutcher's hairline and how some people think it looks good for his age, while others criticize it. Some mention that he used to use medication for hair loss but stopped.

community 3 months on topical min. 1 year on fin. Micro-needling every couple of weeks.

in Progress Pictures 152 upvotes 1 year ago

User shared progress with 3 months on topical minoxidil, 1 year on finasteride, and micro-needling every couple of weeks. Others praised hair growth and shared reactions.

community Fin and min are literally magic

in Research/Science 44 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, with one user experiencing significant hair regrowth after 6 months using minoxidil at night, finasteride in the morning, microneedling every three days, a healthy lifestyle, vitamins, and a specific shampoo. Another user is inquiring about the timeframe for seeing results with minoxidil.

community 6 months on oral minox with no result

in Minoxidil 10 upvotes 2 years ago

A user who had taken oral minoxidil for 6 months without seeing any results and the advice given in response, which included trying microneedling in combination with topical minoxidil, as well as seeking a dermatologist's opinion.

community POV: You Ask A Tressless User If It's Safe To Drink Minoxidil

in Satire 769 upvotes 2 years ago

This conversation is about how topical treatments for hair loss, such as Minoxidil and Finasteride, can be replaced by drinking oral versions of the same medications to achieve better results with less hassle. Some users have already been doing this with positive results.

community Future hope ? What do you guys predict ? clascoterone, pyrilutamide, gt20029 etc.

in Treatment 15 upvotes 3 years ago

User tried oral finasteride, topical finasteride, topical dutasteride, and RU58841 but experienced side effects. They discuss upcoming treatments like clascoterone, pyrilutamide, gt20029, and KY19382 as potential options.

community 6 months after FUE. I know hair is longer and different light, but the resultat is amazing so far. Confidence is skyhigh!

in Transplants 3 years ago

User had successful FUE hair transplant with 3500 grafts, costing 3900 euros at Novohair in Berlin, gaining confidence. User lost hair due to chemo, family history of hair loss at 40-50 years old.