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GlossaryEstradiol (17beta-estradiol)

potent estrogen hormone primarily produced in the ovaries

Estradiol, also known as 17β-Estradiol or E2, is a potent estrogen hormone primarily produced in the ovaries. It plays a crucial role in regulating the menstrual cycle, reproductive system, and secondary sexual characteristics in females. Additionally, estradiol has significant effects on various tissues, including bone, skin, and hair, influencing growth and maintenance.

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research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids

26 citations, March 2006 in “Endocrine, metabolic & immune disorders. Drug targets”

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

research Testosterone Metabolism in Human Skin Cells In Vitro and Its Interaction with Estradiol and Dutasteride

21 citations, January 2003 in “Skin pharmacology and physiology”

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

research Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

56 citations, February 2006 in “American journal of physiology. Cell physiology”

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

research Review of the Effects of 17α-Estradiol in Humans: A Less Feminizing Estrogen with Neuroprotective Potential

26 citations, February 2009 in “Drug Development Research”

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

research Aromatase Deficiency in a Male Patient: Case Report and Literature Review

36 citations, October 2016 in “Bone”

A male with aromatase deficiency improved bone health with estradiol treatment.

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community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 184 upvotes 2 weeks ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 8 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community 2 months on minoxidil 5% GOOD RESULTS?

in Progress Pictures 2 years ago

Asteride into your routine In this conversation, the user Icy-Indication267 was asking when they should start finasteride to treat their hair loss, which had responded well to minoxidil after two months. Other users shared advice on incorporating micro-needling and topical finasteride into their routine for optimal results.

community Why am I so scared to start fin?

in Finasteride/Dutasteride 15 upvotes 2 years ago

User is scared to start finasteride for hair loss due to potential side effects and personal concerns. Another user suggests trying a low dose for 6 months and avoiding online groups to reduce anxiety.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

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