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    Glossary Agouti Signaling Protein

    protein influencing hair color by inhibiting melanocortin 1 receptor

    Agouti Signaling Protein (ASIP) is a protein that plays a crucial role in determining hair color in mammals. It works by inhibiting the action of the melanocortin 1 receptor (MC1R), which leads to the production of yellow or red pigments (pheomelanin) instead of black or brown pigments (eumelanin). This protein is also involved in various biological processes, including energy metabolism and obesity.

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    Research 30 of 189

    1. Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores Journal of Biological Chemistry · 1999 · 43 citations
    2. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    3. Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds Genetics selection evolution · 2019 · 30 citations
    4. Efficacy of an agonist of<i>α</i>-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation International Journal of Cosmetic Science · 2018 · 12 citations
    5. Piecing together the pigment-type switching puzzle Pigment cell & melanoma research · 2009 · 10 citations
    6. The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice International Journal of Molecular Sciences · 2019 · 2 citations
    7. Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement Genes · 2024
    8. Siberian cats help in solving part of the mystery surrounding golden cats Animal Genetics · 2021 · 7 citations
    9. Agouti and Agouti-related Protein: Analogies and Contrasts Journal of Biological Chemistry · 2000 · 135 citations
    10. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    11. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    12. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    13. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    14. β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010 · 314 citations
    15. Sox2 in the dermal papilla regulates hair follicle pigmentation Cell reports · 2022 · 9 citations
    16. Fundamental hair follicle biology and fine fibre production in animals animal · 2010 · 170 citations
    17. Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity ˜The œInternational journal of developmental biology · 2009 · 64 citations
    18. High doses of cobalt inhibited hair follicle development in Rex Rabbits World rabbit science · 2019 · 1 citations
    19. The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics Animals · 2022 · 1 citations
    20. Fibroblasts: Origins, definitions, and functions in health and disease Cell · 2021 · 488 citations
    21. How the leopard gets its spots: a transmembrane peptidase specifies feline pigmentation patterns Pigment Cell & Melanoma Research · 2013
    22. Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors Asian-Australasian journal of animal sciences · 2016 · 1 citations
    23. Expression and tissue distribution analysis of vimentin and transthyretin proteins associated with coat colors in sheep (Ovis aries) Animal Bioscience · 2023
    24. Fibroblast heterogeneity: implications for human disease Journal of Clinical Investigation · 2018 · 299 citations
    25. Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re‐discovered Experimental Dermatology · 2006 · 117 citations
    26. Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies Experimental Dermatology · 2020 · 15 citations
    27. Computational derivation of a molecular framework for hair follicle biology from disease genes Scientific Reports · 2017 · 4 citations
    28. Dermal papilla regulation of hair growth and pigmentation Advances in stem cells and their niches · 2019 · 3 citations
    29. Natural Skin Whitening Compounds: Types, Source and Mechanism of Action: A Review African Scientific Reports · 2023 · 1 citations
    30. Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/− Mice American Journal of Pathology · 2014 · 8 citations