TLDR The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.
In the 2017 study, researchers created a comprehensive archive of 684 genes associated with monogenic hair disorders to improve diagnostic sequencing and understanding of hair follicle biology. They performed an annotation enrichment analysis, identifying 4,937 significantly enriched molecular annotations and constructed a hair follicle signaling network, which revealed the previously unrecognized role of the Hippo signaling pathway. Hierarchical clustering was used to identify 35 gene clusters representing biological modules, potentially useful for a new biology-based disease taxonomy. The study also found significant enrichment in cancer pathways and suggested the immune system's involvement in hair follicle biology. This work aimed to facilitate precision medicine and suggested further investigation into the biological modules and their disease links. The study provides a framework for understanding hair follicle disease biology and highlights the Hippo signaling pathway for future research in hair growth.
64 citations,
March 2017 in “Nature communications” Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
119 citations,
November 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
46 citations,
April 2016 in “Journal of Investigative Dermatology” New genes found linked to balding, may help develop future treatments.
159 citations,
October 2015 in “Science Advances” Blocking JAK-STAT signaling can lead to hair growth.
136 citations,
July 2014 in “Proceedings of the National Academy of Sciences of the United States of America” FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.
52 citations,
October 2012 in “Journal of Dermatological Science” The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.
116 citations,
September 2001 in “Journal of The American Academy of Dermatology” Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
4 citations,
November 2017 in “Scientific Reports” The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.
