Synergistic Effect of Soursop Leaf Extract (Annona Muricata Linn) and Doxorubicin on MCF-7 Breast Cancer Cells

The study explores the synergistic effect of combining soursop leaf extract with doxorubicin on MCF-7 breast cancer cells. Soursop leaf extract showed anticancer properties with an IC50 of 58.75 µg/mL, while doxorubicin had a stronger effect with an IC50 of 1.34 µg/mL. The combination demonstrated a moderate synergistic effect, with a synergy index of 0.8-1.0, suggesting it could enhance therapeutic efficacy and potentially reduce the side effects of doxorubicin, such as hair loss.