Synergistic Effect of Soursop Leaf Extract (Annona Muricata Linn) and Doxorubicin on MCF-7 Breast Cancer Cells

    October 2024 in “ Media Farmasi ”
    Lukman Lukman, Hijral Aswad, Desy Lestari, Andi Paluseri
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    🚨 The study mentions the potential reduction of doxorubicin side effects, including hair loss, but the primary focus is on breast cancer treatment, not hair-related issues.
    TLDR Combining soursop leaf extract with doxorubicin may improve breast cancer treatment and reduce side effects.
    The study explores the synergistic effect of combining soursop leaf extract with doxorubicin on MCF-7 breast cancer cells. Soursop leaf extract showed anticancer properties with an IC50 of 58.75 µg/mL, while doxorubicin had a stronger effect with an IC50 of 1.34 µg/mL. The combination demonstrated a moderate synergistic effect, with a synergy index of 0.8-1.0, suggesting it could enhance therapeutic efficacy and potentially reduce the side effects of doxorubicin, such as hair loss.
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