Benzothiazepines, Diltiazem, and JTV-519 Exert Anxiolytic-Like Effects via Neurosteroid Biosynthesis in Mice

    March 2020 in “ Journal of Pharmacological Sciences ”
    Kazumi Yoshizawa, Kozue Nakashima, Mizuho Tabuchi, Ayano Okumura, Yuko Nakatake, Mitsuhiko Yamada, Yayoi Tsuneoka, Tatsuya Higashi
    Image of study
    TLDR Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.
    The study from July 2020 demonstrated that benzothiazepines, including diltiazem and JTV-519, have anxiolytic-like effects in mice, which are mediated by the biosynthesis of neurosteroids. These effects were comparable to those of carbamazepine and were inhibited by finasteride, suggesting the involvement of neurosteroid biosynthesis. The study, which used a minimum of six mice per experimental replication, also indicated that sodium valproate operates through a different mechanism, as its effects were not suppressed by finasteride. While classical benzodiazepines act on GABAA receptors and the translocator protein (TSPO), benzothiazepines and benzoxazepines selectively target TSPO. The study did not measure the increase in the neurosteroid allopregnanolone (ALLO) levels but concluded that benzothiazepines could be potential treatments for anxiety related to cardiovascular disease due to their anxiolytic-like effects and the cardioprotective properties of JTV-519.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Breezula CB-03-01

      in Treatment  12 upvotes 4 years ago
      The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

      community Six months of only Dermarolling

      in Progress Pictures  157 upvotes 1 year ago
      User tried dermarolling for hair loss and shared progress pictures. Some suggest adding finasteride and minoxidil, while others debate effectiveness and frequency of dermarolling.

      community People who tolerate dut better than fin?

      in Finasteride/Dutasteride  32 upvotes 2 months ago
      Dutasteride may have fewer side effects than finasteride, with some users experiencing better hair maintenance. Experiences vary, with some preferring dutasteride for fewer side effects, while others see no significant hair improvement.

      community Finasteride affects both 5a reductase and 5b reductase

       6 upvotes 5 years ago
      Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

    Related Research

    7 / 7 results