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    Glossary Translocator Protein

    protein on mitochondria involved in cholesterol transport and stress response

    The Translocator Protein (TSPO), formerly known as the Peripheral Benzodiazepine Receptor (PBR), is a protein found on the outer membrane of mitochondria, the energy-producing structures in cells. It plays a crucial role in transporting cholesterol into mitochondria, which is essential for the production of steroid hormones. TSPO is also involved in cellular stress responses and inflammation, making it a target for research in various medical fields, including neurology and oncology.

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    1. Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice Behavioural Pharmacology · 2017 · 7 citations
    2. Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa Biomedicine & pharmacotherapy · 2018 · 3 citations
    3. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    4. Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects Neuropharmacology · 2017 · 25 citations
    5. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    6. Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis PLoS ONE · 2014 · 56 citations
    7. Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers Journal of Cellular Biochemistry · 2017 · 15 citations
    8. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations
    9. Role of neurosteroids in the anticonvulsant activity of midazolam British Journal of Pharmacology · 2011 · 28 citations
    10. Over-expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction caused by lipopolysaccharide in mice Brain Research · 2016 · 18 citations
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