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Glossary Ten-Eleven Translocation Methylcytosine Dioxygenase

enzyme that modifies DNA to regulate gene expression

Ten-Eleven Translocation Methylcytosine Dioxygenase, often abbreviated as TET, is an enzyme that plays a crucial role in DNA demethylation, a process that can activate or deactivate genes. TET enzymes modify methylated cytosines (a component of DNA) by converting them into hydroxymethylcytosines, which can then be further processed to remove the methyl group entirely. This activity is essential for regulating gene expression and maintaining normal cellular functions, and disruptions in TET function have been linked to various diseases, including cancer.

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DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

This study found that ablation of Tet2/Tet3 genes in skin epithelial cells altered hair shape and length, leading to hair loss, by affecting chromatin accessibility and gene expression related to hair follicle regulation.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Keratinocyte Differentiation and Hair Growth

research 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the ablation of Tet2/Tet3 genes in mouse skin epithelial cells led to altered hair shape and length, highlighting their role in regulating hair follicle gene expression and chromatin structure.

research 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

3 citations , April 2025 in “International Journal of Molecular Sciences”

This review evaluates the anti-aging properties of TSG from He shou wu, finding it may protect against age-related diseases through multiple mechanisms, though further research is needed for clinical application.

research DNA Methylation as an Epigenetic Memory Keeper during Skin Development and Regeneration

1 citations , January 2018 in “Stem cell biology and regenerative medicine”

This review discusses the roles of DNA methylation in skin development and regeneration, highlighting its impact on embryonic skin lineage, homeostasis, and potential therapeutic targets, but reports no new clinical results.

research Exploring Nanotechnology With Traditional Herbal Pharmacology: Nano Carrier-Based Phytochemical Delivery In PCOS Treatment

July 2025

This chapter reviews the challenges and future prospects of using nanotechnology and phytochemistry in developing safe, effective, and precision-based therapies for Polycystic Ovary Syndrome, without reporting new clinical findings.

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Hair Loss Treatments
Clinic TEN ShibuyaShibuya · JP

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