Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats

April 2007 in “ European Journal of Pharmacology ”

Ajaykumar N. Sharma, Chandrabhan T. Chopde, Khemraj Hirani, Dadasaheb M. Kokare, Rajesh R. Ugale

progesterone allopregnanolone dehydroepiandrosterone sulphate DHEAS GABAA receptors finasteride neurosteroids DHEA

TLDR Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.

The study investigated the effects of neurosteroids on ethanol-induced anxiolysis and withdrawal anxiety in rats. It found that chronic progesterone treatment, which increases levels of the neurosteroid allopregnanolone, augmented the development of tolerance to the anxiolytic effects of ethanol and withdrawal anxiety. In contrast, dehydroepiandrosterone sulphate (DHEAS), a negative modulator of GABAA receptors, and finasteride, which inhibits the conversion of progesterone to allopregnanolone, prevented these effects. The research highlighted the differential roles of GABAergic neurosteroids in ethanol tolerance and dependence, suggesting potential therapeutic targets for managing alcohol-related anxiety disorders.

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Effects of Finasteride on Chronic and Acute Ethanol Withdrawal Severity in the WSP and WSR Selected Lines

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research Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats

27 citations , April 2007 in “European Journal of Pharmacology”

Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.

research Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice

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Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats

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research Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats

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