Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and Delta-Subunit-Containing Gamma-Aminobutyric Acid A Receptors

    November 2018 in “ ˜The œjournal of pain/Journal of pain ”
    Xuhui Chen, Zuofan Li, Bo Zhang … Yue Zhang
    Studysummary This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.
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    Research cited in this study 3

    1. Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures PLoS ONE · 2013
    2. Implication of Allopregnanolone in the Antinociceptive Effect of N-Palmitoylethanolamide in Acute or Persistent Pain Pain · 2011
    3. Neurosteroid Synthesis-Mediated Regulation of GABA A Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007

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