Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and Delta-Subunit-Containing Gamma-Aminobutyric Acid A Receptors

November 2018 in “ The journal of pain/Journal of pain ”

Xuhui Chen, Zuofan Li, Bo Zhang, Rong Hu, Jiayan Li, Miaomiao Feng, Wenlong Yao, Chuanhan Zhang, Li Wan, Yue Zhang

finasteride dutasteride allopregnanolone steroidogenic acute regulatory protein 14,15-epoxyeicosatrienoic acid δGABAAR bicuculline gabapentin Propecia Avodart AP 14,15-EET delta-GABAAR

TLDR 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

The study investigated the effects of 14,15-epoxyeicosatrienoic acid (14,15-EET) on mechanical allodynia in a central poststroke pain (CPSP) model using rats. It found that 14,15-EET alleviated mechanical allodynia by enhancing StAR-AP-δGABAAR signaling, showing greater efficacy than gabapentin. The antinociceptive effect was negated by inhibitors of 5α-reductase or GABAAR antagonists, suggesting that 14,15-EET could be a potential therapeutic agent for CPSP by restoring normal thalamic inhibition through AP-δGABAAR signaling. The study involved groups of 5 to 10 rats per experiment.

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