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Research

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research A Review of Keratin-Based Biomaterials for Biomedical Applications

517 citations , February 2010 in “Materials”

This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.

research 40nm, but not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells after Transcutaneous Application on Human Skin

323 citations , April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that 40 nm nanoparticles can effectively penetrate into hair follicles and epidermal Langerhans cells in human skin samples, potentially enabling efficient transcutaneous vaccine delivery.

research A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds

319 citations , March 2023 in “Science Advances”

This study demonstrated that a wearable bioelectronic patch with combined therapy significantly accelerated chronic wound healing in a rodent model by monitoring and treating wounds noninvasively.

research Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

282 citations , April 2007 in “Journal of Agricultural and Food Chemistry”

This study found that apple polyphenol extract, particularly oligomeric procyanidins, inhibited pancreatic lipase activity and reduced triglyceride absorption in both mice and humans.

research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

253 citations , March 1994 in “Developmental dynamics”

This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.

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Community Join

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community Applying topical Minoxidil 5% with a fine mist device vs drops?

7 upvotes 4 weeks ago

A user discusses using a fine mist device to apply 5% topical minoxidil for more even coverage on thinning hair compared to using drops. They are also taking oral finasteride and minoxidil, and are exploring if the mist method is as effective long-term.

community Approx. 3 months (12 weeks and 3 days / 88 days total) on 1mg Finasteride

59 upvotes 1 month ago

A 27-year-old male has been using 1mg finasteride daily for hair loss and noticed improved crown density after three months. He previously used topical minoxidil but stopped due to scalp irritation and is considering oral minoxidil or a hair transplant in the future.

community April to July progress minoxidil and iron

in Progress Pictures 31 upvotes 2 months ago

The user experienced improved hair density using minoxidil and iron supplements. They take 2.5 mg oral minoxidil and 60 mg iron gummies.

community how do u guys apply minxoidil if you have long hair.

in Minoxidil 30 upvotes 2 months ago

Applying minoxidil with long hair can be challenging due to its oily appearance, but users suggest methods like using a topical applicator, parting hair, or applying to damp hair. Some prefer oral minoxidil for ease, while others use foam or adjust application techniques to target the scalp effectively.

community Approx 1 year on finestride 1 mg

in Journals / Progress Pictures 23 upvotes 3 months ago

The user shared progress pictures after approximately one year of using finasteride 1 mg for hair loss. They requested opinions on the results shown in the photos.

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Learn

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learn apigenina

learn apple polyphenol

learn Apple Cider Vinegar

learn Apple fruit extract

learn Apple stem cell

learn PP405

Can applying a mask with PP405 directly to thinning areas give your scalp the push it needs? No PP405 mask exists to test: PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, it is not an anti-DHT ingredient, and it is not on sale. Its registered Phase 2 trial (NCT06393452) measured safety, not regrowth, and a rinse-out mask is in any case the wrong format for reaching the follicle.

learn Estradiol

Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.

learn Exosomes

Are exosomes applied as a serum, an injection, or combined with other hair treatments? Clinics offer exosomes as scalp injections, as serums applied after microneedling, or combined with PRP. No exosome product is FDA-approved, and no reliable evidence shows that any of these methods works.

learn Fluridil

Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men; placebo-controlled for 3 months, then all on fluridil to 9 months) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.

learn Follistatin

Can follistatin be applied to the skin, and does any form of it treat hair loss? No study shows that follistatin applied to the skin works, and no form of follistatin is an approved or proven hair-loss treatment. Follistatin injections, "research peptides" and gene therapies sold outside regulated trials are unapproved and of unknown safety.

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