Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

    July 2012 in “ Epilepsy & Behavior ”
    Doodipala Samba Reddy, G. Ramanathan
    Studysummary This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.
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    Research cited in this study 12

    1. A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy Journal of Pharmacology and Experimental Therapeutics · 2012
    2. Ovarian Cycle-Related Neurosteroid Regulation of GABA-A Receptor Subunit Plasticity in the Hippocampus Subfields The FASEB Journal · 2011
    3. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    4. Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy Frontiers in Endocrinology · 2011
    5. Neurosteroids And Epileptogenesis In The Pilocarpine Model: Evidence For A Relationship Between P450scc Induction And Length Of The Latent Period Epilepsia · 2009
    6. Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice Neuroscience · 2007
    7. Endogenous Neurosteroids Modulate Epileptogenesis in a Model of Temporal Lobe Epilepsy Experimental Neurology · 2006
    8. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    9. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    10. Testosterone Modulation of Seizure Susceptibility Is Mediated by Neurosteroids 3α-Androstanediol and 17β-Estradiol Neuroscience · 2004
    11. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    12. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997

    Related research 2

    1. Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis Epilepsy & Behavior · 2012
    2. A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy Journal of Pharmacology and Experimental Therapeutics · 2012