Membrane Androgen Receptors May Mediate Androgen Reinforcement

    February 2010 in “ Psychoneuroendocrinology ”
    Satoru M. Sato, Jamie A. Johansen, Cynthia L. Jordan, Ruth I. Wood
    TLDR Androgen self-administration might be controlled by membrane receptors, not nuclear ones.
    The study demonstrated that androgen self-administration in rats and hamsters was mediated by membrane-associated androgen receptors rather than classical nuclear androgen receptors. Both wild-type (WT) and testicular feminization mutant (Tfm) rats showed a preference for self-administering dihydrotestosterone (DHT) over a vehicle, with no significant genotype differences. Hamsters also preferred DHT and its conjugates over BSA alone. The findings suggested that androgens might act at the neuronal plasma membrane to exert reinforcing effects, as evidenced by the self-administration behavior and the lack of necessity for nuclear androgen receptors. The study also highlighted species-specific differences in operant responding and noted potential caveats such as the in vivo degradation of DHT-BSA conjugates.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 15 years of finasteride/minoxidil

      in Update  194 upvotes 7 months ago
      A user shared a 15-year experience using minoxidil and finasteride for hair loss, stating that despite never missing a dose, their hairline continued to recede slowly. Other users suggested that the hair loss might be exacerbated by the use of steroids and recommended considering other treatments like dutasteride and RU58841.

      community How to Keep Your Hair on Steroids

      in Treatment  19 upvotes 3 months ago
      To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 2 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

      community Hair much worse after 6 months?

      in Progress Pictures  230 upvotes 1 year ago
      A user experienced significant hair loss after 6 months of using 0.5mg finasteride daily. Suggestions from others included trying Dutasteride and Minoxidil, getting professional help from a dermatologist, and addressing high iron levels that could be contributing to the hair loss.

    Similar Research

    5 / 1000+ results