Allopregnanolone Is Required for Prepulse Inhibition Deficits Induced by D1 Dopamine Receptor Activation

June 2019 in “ Psychoneuroendocrinology ”

Laura J. Mosher, Roberto Cadeddu, Sabrina Yen, Jeff Staudinger, Francesco Traccis, Stephen C. Fowler, Jamie Maguire, Marco Bortolato

allopregnanolone 5α-reductase type 1 D1 dopamine receptor GABA-A receptor PXR receptor AP 5αR1

TLDR Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

The study demonstrated that the enzyme 5α-reductase type 1 (5αR1) was necessary for the prepulse inhibition (PPI) deficits induced by D1 dopamine receptor activation in mice. Knockout mice lacking 5αR1 were resistant to these deficits, which were restored by administering allopregnanolone (AP), but not other 5α-reduced steroids. The PPI-disrupting effects of the D1 receptor agonist were not influenced by GABA-A or PXR receptors, indicating that 5αR1 facilitates the negative impact of D1 receptor activation on information processing through the production of AP, independent of these receptors.

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