Effect of 5-Alpha Reductase Inhibitors in Animal Models of Parkinson's Disease

    September 2024 in “ Frontiers in Neuroendocrinology ”
    Mélanie Bourque, Marc Morissette, Amandine Isenbrandt … Thérèse Di Paolo
    🚨 The study involves 5-alpha reductase inhibitors, specifically finasteride and dutasteride, which are relevant to hair loss treatments, but the focus is on neuroprotection in Parkinson's disease rather than hair-related issues.
    Studysummary In this review, the researchers reported that 5α-reductase inhibitors demonstrated neuroprotective effects and reduced dyskinesias in animal models of Parkinson's disease, suggesting their potential for repurposing to manage symptoms in men with PD.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 22

    1. Emerging and Traditional 5-Alpha Reductase Inhibitors and Androgen Receptor Antagonists for Male Androgenetic Alopecia Expert opinion on emerging drugs · 2024
    2. Pregnenolone for the Treatment of L-DOPA-Induced Dyskinesia in Parkinson's Disease Experimental neurology · 2023
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    19. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
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