The Steroidogenic Inhibitor Finasteride Reverses Pramipexole-Induced Alterations in Probability Discounting

The study found that the steroidogenic inhibitor finasteride effectively reverses the probability-discounting alterations induced by pramipexole in rats pre-exposed to mild reserpine treatment. This suggests that finasteride has anti-impulsive properties and could potentially mitigate pramipexole-induced impulse-control disorders. The findings build on previous evidence of finasteride's ability to reduce impulsivity and opioid-seeking behavior, highlighting its potential as a novel therapeutic strategy for managing impulse-control disorders in Parkinson's disease patients.