The Steroidogenic Inhibitor Finasteride Reverses Pramipexole-Induced Alterations in Probability Discounting

February 2022 in “ Brain Research Bulletin ”

Gabriele Floris, Simona Scheggi, Romina Pes, Marco Bortolato

finasteride steroidogenic inhibitor Propecia

TLDR Finasteride may help reduce impulsivity caused by pramipexole.

The study found that the steroidogenic inhibitor finasteride effectively reverses the probability-discounting alterations induced by pramipexole in rats pre-exposed to mild reserpine treatment. This suggests that finasteride has anti-impulsive properties and could potentially mitigate pramipexole-induced impulse-control disorders. The findings build on previous evidence of finasteride's ability to reduce impulsivity and opioid-seeking behavior, highlighting its potential as a novel therapeutic strategy for managing impulse-control disorders in Parkinson's disease patients.

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Research cited in this study

22 / 22 results

research The 5α-Reductase Inhibitor Finasteride Reduces Opioid Self-Administration in Animal Models of Opioid Use Disorder

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Finasteride may cause suicidal thoughts and mental side effects, especially in young people with hair loss.

research Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

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Finasteride shows promise for female hair loss, but more research needed.

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Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

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Finasteride reduces response to stress and rewards, affecting behavior and mental health.

research Post-Finasteride Syndrome

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Post-finasteride syndrome causes sexual, physical, and psychological symptoms, but more research is needed to understand its causes and connection to finasteride.

research The Efficacy and Use of Finasteride in Women: A Systematic Review

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Finasteride improves hair growth and reduces hirsutism in women, but side effects and optimal dosages need further research.

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research 5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction

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research Repurposing Steroidogenesis Inhibitors for the Therapy of Neuropsychiatric Disorders: Promises and Caveats

10 citations, May 2018 in “Neuropharmacology”

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

research Clinical Efficacy of Oral Administration of Finasteride at a Dose of 2.5 mg/Day in Women with Female Pattern Hair Loss

13 citations, February 2018 in “Dermatologic Therapy”

Finasteride 2.5 mg/day can effectively treat female hair loss.

research Allopregnanolone Mediates the Exacerbation of Tourette-Like Responses by Acute Stress in Mouse Models

25 citations, June 2017 in “Scientific reports”

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

research The 5-Alpha Reductase Inhibitor Finasteride Reduces Dyskinesia in a Rat Model of Parkinson’s Disease

15 citations, January 2017 in “Experimental Neurology”

Finasteride reduces movement issues in Parkinson's disease rats.

research The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation

27 citations, January 2017 in “Neuropsychopharmacology”

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

research Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study

69 citations, July 2015 in “Pharmacotherapy”

Low-dose finasteride may cause lasting sexual dysfunction and suicidal thoughts in young men.

research Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress

24 citations, May 2015 in “Schizophrenia Research”

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

research Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride

81 citations, June 2014 in “American Journal of Men's Health”

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

research Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects

134 citations, August 2012 in “The Journal of Clinical Psychiatry”

Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.

research Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease

35 citations, June 2012 in “Journal of Clinical Psychopharmacology”

Finasteride reduces gambling symptoms in Parkinson's patients.

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

72 citations, January 2011 in “Current Pharmaceutical Design”

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

research Finasteride Induced Depression: A Prospective Study

99 citations, October 2006 in “BMC clinical pharmacology”

Finasteride may cause slight depression and anxiety.

research Low-Dose (2.5 mg/Day) Finasteride Treatment in Hirsutism

18 citations, January 2003 in “Gynecological Endocrinology”

Low-dose finasteride effectively reduces hirsutism without serious side-effects.

A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

research A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

113 citations, April 1999 in “The Journal of Clinical Endocrinology and Metabolism”

Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.

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Related Research

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