The Steroidogenic Inhibitor Finasteride Reverses Pramipexole-Induced Alterations in Probability Discounting

    February 2022 in “ Brain Research Bulletin
    Gabriele Floris, Simona Scheggi, Romina Pes, Marco Bortolato
    TLDR Finasteride may help reduce impulsivity caused by pramipexole.
    The study found that the steroidogenic inhibitor finasteride effectively reverses the probability-discounting alterations induced by pramipexole in rats pre-exposed to mild reserpine treatment. This suggests that finasteride has anti-impulsive properties and could potentially mitigate pramipexole-induced impulse-control disorders. The findings build on previous evidence of finasteride's ability to reduce impulsivity and opioid-seeking behavior, highlighting its potential as a novel therapeutic strategy for managing impulse-control disorders in Parkinson's disease patients.
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