Progesterone and Its Metabolites: Anticonvulsant and Behavioral Studies

June 2014 in “ Belarusian State Pedagogical University repository (Belarusian State Pedagogical University) ”

Allison Melanie Jeffrey

progesterone 5-alpha-dihydroprogesterone 3-alpha,5-alpha-tetrahydroprogesterone finasteride DHP THP Propecia

TLDR Progesterone and its metabolites can prevent seizures without major side effects.

The study explored the anticonvulsant properties of progesterone and its metabolites, particularly focusing on 5-alpha-dihydroprogesterone (DHP) and 3-alpha,5-alpha-tetrahydroprogesterone (THP). Behavioral experiments in amygdala-kindled rats showed that anticonvulsant doses of DHP and THP (5-10 mg/kg) did not cause significant psychotoxicity in tests for anxiety, depression, locomotion, and learning. Electrophysiological studies in mice revealed that progesterone had anticonvulsant effects independent of its metabolites, suggesting a non-GABAergic mechanism. High doses of progesterone were effective even when its metabolism to DHP and THP was inhibited, indicating a novel anticonvulsant action.

View this study on hdl.handle.net →

Discuss this study in the Community →

Related Community Posts Join

6 / 179 results

community Finastride is a god send miracle FOR ME

in Finasteride/Dutasteride 203 upvotes 3 years ago

. This user experienced positive results from using a combination of minoxidil and finasteride, with no reported side effects after two months. Others have also shared their experiences with both short-term and long-term use of finasteride.

community I've been afraid to start Finasteride treatment for 5 years, on it for 2 weeks, regret that hadn't started it earlier and here's my story

in Finasteride/Dutasteride 32 upvotes 4 years ago

A 28-year-old male, losing hair since his teens, started taking 0.31 mg finasteride daily for two weeks with no side effects and regrets not starting earlier. He tried various treatments like minoxidil, scalp massages, and vitamins but found finasteride most effective.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 67 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community risks with finasteride and dutasteride

in Research/Science 138 upvotes 5 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

in Finasteride/Dutasteride 290 upvotes 6 months ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

Related Research

2 / 2 results

research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

26 citations , July 2012 in “Epilepsy & Behavior”

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

research A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy

49 citations , March 2012 in “Journal of Pharmacology and Experimental Therapeutics”