A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy

    March 2012 in “ Journal of Pharmacology and Experimental Therapeutics ”
    Doodipala Samba Reddy, Jordan Gould, Omkaram Gangisetty
    Studysummary This study developed a novel mouse model of catamenial epilepsy by manipulating neurosteroid levels and demonstrated that withdrawal increases seizure susceptibility, potentially linked to changes in GABAA receptor-subunit plasticity.
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    Research cited in this study 6

    1. Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy Frontiers in Endocrinology · 2011
    2. Finasteride Treatment and Neuroactive Steroid Formation PubMed · 2009
    3. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    4. Neurosteroid Synthesis-Mediated Regulation of GABA A Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007
    5. Effect of Neurosteroid Withdrawal on Spontaneous Recurrent Seizures in a Rat Model of Catamenial Epilepsy The FASEB Journal · 2007
    6. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004