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GlossaryAllopregnanolone (THP)

neurosteroid derived from progesterone that modulates brain activity

Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

research 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

18 citations , March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.

research Investigating the Use of Autologous Stem Cell Therapy in the Treatment of Androgenetic Alopecia

September 2024 in “British journal of surgery”

Autologous stem cell therapy may effectively increase hair density in Androgenetic Alopecia.

research Hippocampal 3α,5α-THP May Alter Depressive Behavior of Pregnant and Lactating Rats

83 citations , July 2004 in “Pharmacology Biochemistry and Behavior”

Higher 3α,5α-THP levels in the brain may reduce depression in pregnant rats.

research Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats

269 citations , May 2002 in “Hormones and Behavior”

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

research HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation

20 citations , December 2019 in “International Journal of Molecular Sciences”

HB-EGF boosts the hair growth ability of stem cells, making it a potential hair loss treatment.

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community 4600 - result 9 month - Dr. Carman

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A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

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Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.