Search

for
Search:

GlossaryAllopregnanolone (THP)

neurosteroid derived from progesterone that modulates brain activity

Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 263 results

research Investigating the Use of Autologous Stem Cell Therapy in the Treatment of Androgenetic Alopecia

September 2024 in “British journal of surgery”

Autologous stem cell therapy may effectively increase hair density in Androgenetic Alopecia.

research Hippocampal 3α,5α-THP May Alter Depressive Behavior of Pregnant and Lactating Rats

83 citations , July 2004 in “Pharmacology Biochemistry and Behavior”

Higher 3α,5α-THP levels in the brain may reduce depression in pregnant rats.

research Thyrotoxic Hypokalemic Periodic Paralysis in a Brazilian Male: A Case Report

January 2024 in “Arquivos de Neuro-Psiquiatria”

Consider THPP in patients with muscle weakness and low potassium, as it is often underdiagnosed.

research Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats

269 citations , May 2002 in “Hormones and Behavior”

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

research Attenuating 5α-Pregnane-3α-Ol-20-One Formation in the Hippocampus of Female Rats Increases Pentylenetetrazole-Induced Seizures

21 citations , February 2005 in “Epilepsy & Behavior”

Reducing 3α,5α-THP in the hippocampus increases seizures in female rats.

View more "thp" in research →

Community Join

2 / 2 results

community 4600 - result 9 month - Dr. Carman

in Progress Pictures 252 upvotes 2 years ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community Why do people here trust Kevin Mann?

in Chat 35 upvotes 5 years ago

Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.