Investigation of the Mechanisms of Progesterone Protection Following Oxygen-Glucose Deprivation in Organotypic Hippocampal Slice Cultures

    November 2011 in “ Neuroscience Letters ”
    Elizabeth Radley, Asha Akram, Blair D. Grubb, Claire L. Gibson
    Studysummary This study reported that progesterone reduces cell death in hippocampal cultures following oxygen–glucose deprivation mainly through its conversion to allopregnanolone and the involvement of GABAA receptors.
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    Research cited in this study 3

    1. GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices European Journal of Neuroscience · 2007
    2. Mechanism of Progesterone Neuroprotection of Rat Cerebellar Purkinje Cells Following Oxygen-Glucose Deprivation European Journal of Neuroscience · 2006
    3. Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective Journal of Neurobiology · 2006

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