Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation

    July 2011 in “ Journal of Neuroscience ”
    Kazuhiro Tokuda, Yukitoshi Izumi, C. F. Zorumski
    Studysummary In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.
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    Research cited in this study 3

    1. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    2. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    3. GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices European Journal of Neuroscience · 2007

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