Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation

July 2011 in “ Journal of Neuroscience ”

Kazuhiro Tokuda, Yukitoshi Izumi, C. F. Zorumski

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Studysummary In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.

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research GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices

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This study found that ethanol's ability to block long-term potentiation in rat hippocampal slices is influenced by neurosteroids that enhance GABA A receptor activity.